Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

Life Sciences, Developmental Biology, Molecular Biology +12

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Medicine, Genetics, Molecular Genetics +15

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

Thomas M. DeChiara, Argiris Efstratiadis, Elizabeth J. Robertsen · Nature · 1990 · 1.7K citations

Medicine, Genetics, Molecular Genetics +13

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

Andrew P. McMahon, Allan Bradley · Cell · 1990 · 1.5K citations

Life Sciences, Developmental Biology, Genetics +11

A mechanism for gene conversion in fungi

Genetics Research · 1964 · 1.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +14