Concepedia

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

Michio Onizawa, Shigeru Oshima, Ulf Schulze‐Topphoff, Juan A. Osés-Prieto, Timothy T. Lu, Rita M. Tavares, Thomas Prod’homme, Bao Duong, Michael I. Whang, Rommel Advincula,

Nature Immunology · 2015 · 279 citations · 46 references

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46

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Jonathan Sherlock, Yi Chen, Craig A. Murphy et al. · Nature · 2003 · 2.9K citations

, , +14

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Liming Sun, Huayi Wang, Zhigao Wang et al. · Cell · 2012 · 2.7K citations · Full text

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Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

Young-Sik Cho, Sreerupa Challa, David Moquin et al. · Cell · 2009 · 2.4K citations · Full text

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Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

Sudan He, Lai Wang, Lin Miao et al. · Cell · 2009 · 2.2K citations

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Ingrid E. Wertz, Karen O’Rourke, Honglin Zhou et al. · Nature · 2004 · 1.8K citations

, , +12