IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Claire L. Langrish, Yi Chen, Wendy M. Blumenschein, +6

The Journal of Experimental Medicine

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

J. Daniel, Jonathan Sherlock, Yi Chen, +13

Nature

InflammationCytokinePsychoneuroimmunologyAutoimmune InflammationCritical Cytokine +12

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

Craig A. Murphy, Claire L. Langrish, Yi Chen, +5

The Journal of Experimental Medicine

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

Mandy J. McGeachy, Kristian Sass Bak‐Jensen, Yi Chen, +4

Nature Immunology

InflammationCytokineT CellsImmunologyT Cell Immunity +6

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

Mandy J. McGeachy, Yi Chen, Cristina M. Tato, +6

Nature Immunology

Terminal DifferentiationCytokineInterleukin 23Immune Cell DevelopmentImmunology +8

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

Jacob S. Lee, Cristina M. Tato, Barbara Joyce-Shaikh, +9

Immunity

InflammationCytokineMucosal ImmunologyImmunologyAutoimmunity +2

IL-25 regulates Th17 function in autoimmune inflammation

Melanie A. Kleinschek, Alexander M. Owyang, Barbara Joyce-Shaikh, +9

The Journal of Experimental Medicine

InflammationCytokineAutoimmune InflammationAutoimmune DiseaseAllergy +12

IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells

Caroline Diveu, Mandy J. McGeachy, Katia Boniface, +10

The Journal of Immunology

The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation

Muhammet F. Gülen, Zizhen Kang, Katarzyna Bulek, +14

Immunity

InflammationCytokineSignal TransductionAutoimmune DiseaseMtor Kinase Activation +11

Foxp3+ Regulatory T Cells Promote T Helper 17 Cell Development In Vivo through Regulation of Interleukin-2

Yi Chen, Christopher J. Haines, Ilona Gutcher, +7

Immunity

InflammationCytokineDevelopmental BiologyAutoimmune DiseaseLymphocyte Development +8