Role of Complement in Motor Neuron Disease: Animal Models and Therapeutic Potential of Complement Inhibitors

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

Mark E. Gurney, Haifeng Pu, Arlene Y. Chiu et al. · Science · 1994 · 4.1K citations

Life Sciences, Genetics, Neuroscience +17

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

Philip C. Wong, Carlos A. Pardo, David Borchelt et al. · Neuron · 1995 · 1.4K citations

Life Sciences, Neurology, Neuroscience +17

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

Andrew G. Reaume, Jeffrey L. Elliott, Eric K. Hoffman et al. · Nature Genetics · 1996 · 1.3K citations

Life Sciences, Neurobiology, Neuroscience +17

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)

David Howland, Jian Liu, Yijin She et al. · Proceedings of the National Academy of Sciences · 2002 · 829 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

M E Ripps, George W. Huntley, Patrick R. Hof et al. · Proceedings of the National Academy of Sciences · 1995 · 712 citations

Life Sciences, Genetics, Neuroscience +17