Principia Biopharma (United States)

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Publications

Citations

21.1K

Authors

Location

South San Francisco, United States

Principia Biopharma (United States) is a company institution in South San Francisco, United States known for pharmacology, medicine, and life sciences.

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Top concepts

PharmacologyBtk InhibitorsPharmacyDrug DiscoveryMedicinal ChemistryBruton's Tyrosine Kinase InhibitorsTyrosine Kinase InhibitorsMedicineBruton Tyrosine KinaseReversible Covalent Inhibitors

Publications

Prolonged and tunable residence time using reversible covalent kinase inhibitors

J. Michael Bradshaw, Jesse M. McFarland, Ville O. Paavilainen et al. · Nature Chemical Biology · 2015 · 430 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-O-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection

Guangyi Wang, Jérôme Deval, Jin Tae Hong et al. · Journal of Medicinal Chemistry · 2015 · 138 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease

Claire L. Langrish, J. Michael Bradshaw, Michelle Francesco et al. · The Journal of Immunology · 2021 · 124 citations · Full text

Life Sciences, Immunology, Pharmacology +17

A phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton's tyrosine kinase, in healthy volunteers

Patrick F. Smith, Janakan Krishnarajah, Philip A. Nunn et al. · British Journal of Clinical Pharmacology · 2017 · 102 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +16

Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors

Ken A. Brameld, Timothy D. Owens, Erik Verner et al. · Journal of Medicinal Chemistry · 2017 · 96 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

1–5 of 81

Authors

JM
J. Michael Bradshaw
Principia Biopharma (United States), United States
49 publications · 2.8K citations
27
h-index
DE
Dane E. Karr
Principia Biopharma (United States), United States
46 publications · 2.5K citations
22
h-index
KA
Ken A. Brameld
Principia Biopharma (United States), United States
43 publications · 2.5K citations
22
h-index
TD
Timothy D. Owens
Principia Biopharma (United States), United States
61 publications · 3.3K citations
22
h-index
EV
Erik Verner
Principia Biopharma (United States), United States
53 publications · 4.4K citations
22
h-index

1–5 of 26