Concepedia

Variable Region Design

Variable Region Design is the systematic engineering of the antigen-binding domains of antibody molecules through computational or experimental methods to achieve specific binding affinity, specificity, and stability properties distinct from naturally occurring sequences.

55

Publications

6.2K

Citations

360

Authors

100

Institutions

Publications per year

2017–2026

14

Parents

Publications

55

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

James S. Huston, Dennis J. Levinson, M Mudgett-Hunter et al. · Proceedings of the National Academy of Sciences · 1988 · 1.6K citations · Full text

, , +17

"Diabodies": small bivalent and bispecific antibody fragments.

Philipp Holliger, Teresa Di Prospero, Greg Winter · Proceedings of the National Academy of Sciences · 1993 · 875 citations · Full text

, , +17

β-Lactamase Inhibitors Derived from Single-Domain Antibody Fragments Elicited in the <i>Camelidae</i>

Katja Conrath, Marc Lauwereys, Moreno Galleni et al. · Antimicrobial Agents and Chemotherapy · 2001 · 342 citations · Full text

, , +16

Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity

Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda et al. · PLoS ONE · 2013 · 325 citations · Full text

, , +17

Reduced elimination of IgG antibodies by engineering the variable region

Tomoyuki Igawa, Hiroyuki Tsunoda, Tatsuhiko Tachibana et al. · Protein Engineering Design and Selection · 2010 · 262 citations

, , +17

1–5 of 55

Authors

360

  1. PJ
    Peter J. Hudson

    Commonwealth Scientific and Industrial Research Organisation, Australia

    3 publications · 176 citations

    3

    h-index

  2. HU
    Hiroshi Ueda

    The University of Tokyo, Japan

    3 publications · 104 citations

    3

    h-index

  3. CD
    Costas D. Maranas

    Pennsylvania State University, United States

    3 publications · 156 citations

    3

    h-index

  4. TT
    Tatsuhiko Tachibana

    Chugai Pharma (United States), United States

    2 publications · 587 citations

    2

    h-index

  5. RC
    Ratul Chowdhury

    Pennsylvania State University, United States

    2 publications · 74 citations

    2

    h-index

1–5 of 360

Institutions

100

  1. Pennsylvania State University

    State College, United States

    4 h-index

    10 publications

    501 citations

  2. Commonwealth Scientific and Industrial Research Organisation

    Canberra, Australia

    3 h-index

    12 publications

    451 citations

  3. Eli Lilly (United States)

    Indianapolis, United States

    3 h-index

    9 publications

    1.1K citations

  4. Kyushu University

    Fukuoka, Japan

    3 h-index

    10 publications

    193 citations

  5. Roche Pharma AG (Germany)

    Grenzach-Wyhlen, Germany

    2 h-index

    5 publications

    268 citations

  6. National Institutes of Health

    Bethesda, United States

    2 h-index

    9 publications

    474 citations

  7. Health Sciences and Nutrition

    Adelaide, Australia

    2 h-index

    15 publications

    958 citations

  8. National Cancer Institute

    Bethesda, United States

    2 h-index

    2 publications

    114 citations

1–8 of 100

Venues

  1. Protein Engineering Design and Selection

    PEDS · 6 publications · 558 citations

    6

    h-index

  2. PubMed

    Repository · 4 publications · 115 citations

    4

    h-index

  3. Molecular Immunology

    4 publications · 249 citations

    4

    h-index

  4. PLoS ONE

    4 publications · 456 citations

    4

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 2.8K citations

    4

    h-index

1–5