Concepedia

Variable Domain Humanization

Variable Domain Humanization is a method in antibody engineering that involves the targeted replacement of non-human variable domain sequences with human counterparts to reduce immunogenicity while preserving antigen-binding specificity.

13

Publications

1.5K

Citations

88

Authors

33

Institutions

Publications per year

2017–2026

3

Parents

Publications

13

General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold

Cécile Vincke, Remy Loris, Dirk Saerens et al. · Journal of Biological Chemistry · 2008 · 584 citations · Full text

, , +17

Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies

Roxana Ionescu, Josef Vlasak, Colleen Price et al. · Journal of Pharmaceutical Sciences · 2007 · 321 citations

, , +13

Humanization of antibodies using a machine learning approach on large-scale repertoire data

Claire Marks, Alissa M. Hummer, Mark Chin et al. · Bioinformatics · 2021 · 127 citations · Full text

, , +15

Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis

Oleg Kovalenko, Andrea Olland, Nicole Piche‐Nicholas et al. · Journal of Biological Chemistry · 2013 · 92 citations · Full text

, , +13

A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing

Michael Roguska, Jan T. Pedersen, Andrew Henry et al. · Protein Engineering Design and Selection · 1996 · 67 citations · Full text

, , +17

1–5 of 13

Authors

88

  1. CJ
    Caroline J. Barelle

    University of Aberdeen, United Kingdom

    2 publications · 139 citations

    2

    h-index

  2. AR
    Anthony R. Rees

    University of Bath, United Kingdom

    2 publications · 99 citations

    2

    h-index

  3. MM
    Mischa Müller

    Pfizer (United Kingdom), United Kingdom

    2 publications · 139 citations

    2

    h-index

  4. MR
    Michael Roguska

    ImmunoGen (United States), United States

    1 publications · 67 citations

    1

    h-index

  5. CC
    Chen-Yi Chiang

    China Medical University, Taiwan

    1 publications · 42 citations

    1

    h-index

1–5 of 88

Institutions

33

  1. University of Aberdeen

    Aberdeen, United Kingdom

    2 h-index

    4 publications

    233 citations

  2. Pfizer (United Kingdom)

    Tadworth, United Kingdom

    2 h-index

    2 publications

    139 citations

  3. National Defense Medical Center

    Taipei, Taiwan

    1 h-index

    1 publications

    42 citations

  4. NKT Therapeutics (United States)

    Waltham, United States

    1 h-index

    1 publications

    67 citations

  5. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    1 h-index

    4 publications

    1.3K citations

  6. Siriraj Hospital

    Bangkok, Thailand

    1 h-index

    3 publications

    42 citations

  7. Joint Center for Structural Genomics

    La Jolla, United States

    1 h-index

    1 publications

    42 citations

  8. ImmunoGen (United States)

    Waltham, United States

    1 h-index

    8 publications

    536 citations

1–8 of 33

Venues

  1. Journal of Biological Chemistry

    JBC · 2 publications · 676 citations

    2

    h-index

  2. Molecular Immunology

    2 publications · 59 citations

    2

    h-index

  3. Protein Engineering Design and Selection

    PEDS · 2 publications · 99 citations

    2

    h-index

  4. Bioinformatics

    1 publications · 127 citations

    1

    h-index

  5. PLoS ONE

    1 publications · 41 citations

    1

    h-index

1–5