Nicole Piche‐Nicholas

Establishing <i>in vitro in vivo</i> correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

Lindsay B. Avery, Jason Wade, Mengmeng Wang et al. · mAbs · 2017 · 97 citations · Full text

Immunocytochemical Technique, Immunology, Pathology +21

Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis

Oleg Kovalenko, Andrea Olland, Nicole Piche‐Nicholas et al. · Journal of Biological Chemistry · 2013 · 90 citations · Full text

Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain

Mischa Müller, Kenneth Saunders, Christopher Grace et al. · mAbs · 2012 · 86 citations · Full text

Medicine, Naïve Vnar Domain, Peptide Library +13

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

Nicole Piche‐Nicholas, Lindsay B. Avery, Amy King et al. · mAbs · 2017 · 74 citations · Full text

Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates

L. Nathan Tumey, Fengping Li, Brian Rago et al. · The AAPS Journal · 2017 · 63 citations

Drug Target, Drug Design, Drug Discovery +13