Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies

Roxana Ionescu, Josef Vlasak, Colleen Price, +1

Journal of Pharmaceutical Sciences

Autoimmune DiseaseImmunologyImmunodominanceAntibody ScreeningAntigen Processing +11

Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys

Fan Jiang, Xiaoping Liang, Melanie Horton, +17

Vaccine

VaccinationVaccine DevelopmentRhesus MonkeysPreclinical StudyImmunology +7

Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies

Weirong Wang, Josef Vlasak, Yunsong Li, +7

Molecular Immunology

InflammationAllergyAutoimmune DiseaseSerum Half-lifeBioanalysis +10

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

Josef Vlasak, Marie Claire Bussat, Shi‐Yi Wang, +7

Analytical Biochemistry

Immunocytochemical TechniqueAllergyAutoimmune DiseaseAsparagine DeamidationPathogenesis +10

Analysis of Kinetics Using a Hybrid Maximum-Entropy/Nonlinear-Least-Squares Method: Application to Protein Folding

Peter Steinbach, Roxana Ionescu, C. Robert Matthews

Biophysical Journal

Protein ChemistryBiophysical ModelingBiochemistryProtein FoldingNatural Sciences +8

Sustained high-titer antibody responses induced by conjugating a malarial vaccine candidate to outer-membrane protein complex

Yimin Wu, Craig T. Przysiecki, Elizabeth Flanagan, +14

Proceedings of the National Academy of Sciences

MalariaImmunologyHigh-titer Antibody ResponsesImmunodominancePlasmodium Falciparum +15

Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody

Sandipan Sinha, Lei Zhang, Shaofeng Duan, +4

Protein Science

ImmunologyGlycobiologyMolecular BiologyProtein PurificationProtein Folding +24

Multistate Equilibrium Unfolding of <i>Escherichia coli</i> Dihydrofolate Reductase:  Thermodynamic and Spectroscopic Description of the Native, Intermediate, and Unfolded Ensembles

Roxana Ionescu, Virginia F. Smith, John C. O'Neil, +1

Biochemistry

Evidence for Trisulfide Bonds in a Recombinant Variant of a Human IgG2 Monoclonal Antibody

Pavlo Pristatsky, Steven L. Cohen, Debra Krantz, +3

Analytical Chemistry

Immunocytochemical TechniqueImmunodeficienciesImmunologyImmunodominanceImmunotherapy +18

Universal Influenza B Vaccine Based on the Maturational Cleavage Site of the Hemagglutinin Precursor

Elisabetta Bianchi, Xiaoping Liang, Paolo Ingallinella, +18

Journal of Virology

VaccinationMaturational Cleavage SiteCross-protectionUniversal Influenza VaccineVaccine Development +12