Concepedia

Ubiquitin-proteasome System Dysfunction

Ubiquitin-Proteasome System Dysfunction is a pathological disruption in the ubiquitin-proteasome pathway characterized by impaired targeting or degradation of ubiquitinated proteins, leading to aberrant protein accumulation and cellular toxicity in neurodegenerative diseases.

1.3K

Publications

106K

Citations

8.7K

Authors

2K

Institutions

Publications per year

2017–2026

393

Variants

Ups Dysfunction

Parents

Publications

1.3K

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

Marco Sandri, Claudia Sandri, Alex Gilbert et al. · Cell · 2004 · 3K citations · Full text

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Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

Marian DiFiglia, Ellen Sapp, Kathryn Chase et al. · Science · 1997 · 2.9K citations

, , +16

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

Neil Bence, Roopal M. Sampat, Ron R. Kopito · Science · 2001 · 2.2K citations

, , +17

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Hideki Shimura, Nobutaka Hattori, Shinichiro Kubo et al. · Nature Genetics · 2000 · 2K citations

, , +14

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Marc Cruts, Ilse Gijselinck, Julie van der Zee et al. · Nature · 2006 · 1.5K citations

, , +11

1–5 of 1.3K

Authors

8.7K

  1. XW
    Xuejun Wang

    University of South Dakota, United States

    20 publications · 1.5K citations

    19

    h-index

  2. FW
    Fred W. van Leeuwen

    Netherlands Institute for Neuroscience, Netherlands

    16 publications · 605 citations

    14

    h-index

  3. JL
    Jie Li

    Augusta University, United States

    11 publications · 1.2K citations

    11

    h-index

  4. RJ
    R. John Mayer

    Queen's Medical Centre, United Kingdom

    11 publications · 890 citations

    11

    h-index

  5. JL
    Jinbao Liu

    Guangzhou Medical University, China

    10 publications · 757 citations

    10

    h-index

1–5 of 8.7K

Institutions

2K

  1. Harvard University

    Cambridge, United States

    34 h-index

    154 publications

    24.5K citations

  2. Inserm

    Paris, France

    32 h-index

    182 publications

    12K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    22 h-index

    125 publications

    8K citations

  4. King's College London

    London, United Kingdom

    19 h-index

    71 publications

    6.6K citations

  5. Kyoto University

    Kyoto, Japan

    19 h-index

    92 publications

    8.1K citations

  6. Baylor College of Medicine

    Houston, United States

    19 h-index

    115 publications

    25.3K citations

  7. Johns Hopkins University

    Baltimore, United States

    18 h-index

    116 publications

    19.8K citations

  8. Columbia University

    New York, United States

    18 h-index

    50 publications

    10.2K citations

1–8 of 2K

Venues

  1. Journal of Biological Chemistry

    JBC · 54 publications · 7.3K citations

    40

    h-index

  2. Human Molecular Genetics

    43 publications · 5K citations

    35

    h-index

  3. PLoS ONE

    45 publications · 1.8K citations

    27

    h-index

  4. Acta Neuropathologica

    35 publications · 2.3K citations

    25

    h-index

  5. Journal of Neurochemistry

    JNC · 29 publications · 2.1K citations

    24

    h-index

1–5