Concepedia

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Hideki Shimura, Nobutaka Hattori, Shinichiro Kubo, Yoshikuni Mizuno, Shuichi Asakawa, Nobuyoshi Shimizu, Kazuhiro Iwaï, Tomoki Chiba, Keiji Tanaka, Toshiaki Suzuki

Nature Genetics · 2000 · 2K citations · 17 references

DOI

Concepts

References

17

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Mihael H. Polymeropoulos, Christian Lavedan, Elisabeth Leroy et al. · Science · 1997 · 8.2K citations

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature · 1998 · 5.2K citations

, , +10

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

Marian DiFiglia, Ellen Sapp, Kathryn Chase et al. · Science · 1997 · 2.9K citations

, , +16

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Kenneth L. Rock, Colette F. Gramm, Lisa Rothstein et al. · Cell · 1994 · 2.5K citations

, , +14

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Kevin L. Lorick, Jane P. Jensen, Shengyun Fang et al. · Proceedings of the National Academy of Sciences · 1999 · 1.2K citations

, , +13