Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori, +5

Nature

Molecular NeuroscienceMendelian DisorderGenetic DisorderGeneticsParkinson Disease +5

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

Clément Gautier, Tohru Kitada, Jie Shen

Proceedings of the National Academy of Sciences

Increased SensitivityMitophagyNeurodegenerative DiseasesMitochondrial FunctionBiochemistry +13

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

Kenji Mizumura, Suzanne M. Cloonan, Kiichi Nakahira, +10

Journal of Clinical Investigation

Mitophagy-dependent Necroptosis ContributesMitophagyAdvanced Lung DiseaseLung InflammationMitochondrial Dysfunction +15

Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

Matthew S. Goldberg, Antonio Pisani, Marián Haburčák, +12

Neuron

GeneticsParkinson DiseaseNeurologyNeuroscienceNeurodegeneration +4

Impaired dopamine release and synaptic plasticity in the striatum of <i>PINK1</i> -deficient mice

Tohru Kitada, Antonio Pisani, Douglas R. Porter, +7

Proceedings of the National Academy of Sciences

Synaptic TransmissionNeurotransmitterSynaptic SignalingSocial SciencesDopaminergic Dysfunction +17

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

Yong Sung Kim, Jeehye Park, Sunhong Kim, +6

Biochemical and Biophysical Research Communications

MitophagySignal TransductionMitochondrial LocalizationCytoskeletonCellular Biochemistry +3

Molecular genetic analysis of a novel <i>Parkin</i> gene in Japanese families with autosomal recessive juvenile parkinsonism: Evidence for variable homozygous deletions in the <i>Parkin</i> gene in affected individuals

Nobutaka Hattori, Tohru Kitada, Hiroto Matsumine, +12

Annals of Neurology

Immunohistochemical and subcellular localization of parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients

Hideki Shimura, Nobutaka Hattori, Shinichiro Kubo, +7

Annals of Neurology

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP

M. Emdadul Haque, Kelly Jean Thomas Craig, Cheryl D’Souza, +7

Proceedings of the National Academy of Sciences

MitophagyMitochondrial FunctionAutophagyMolecular BiologyCell Death +10

Absence of nigral degeneration in aged parkin/DJ‐1/PINK1 triple knockout mice

Tohru Kitada, Youren Tong, Clément Gautier, +1

Journal of Neurochemistry

AgingCell DeathEvoked Dopamine ReleaseStriatal DopamineDegenerative Pathology +14