PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Derek P. Narendra, Seok Min Jin, Atsushi Tanaka, +5

PLoS Biology

Pink1 AccumulationMitophagyActivate ParkinMitochondrial DysfunctionGenetics +16

α-Synuclein is phosphorylated in synucleinopathy lesions

Hideo Fujiwara, Masato Hasegawa, Naoshi Dohmae, +6

Nature Cell Biology

Neurodegenerative DiseasesMolecular NeuroscienceMolecular BiologyDegenerative PathologyProtein Misfolding +6

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

James Palacino, Dijana Šagi, Matthew S. Goldberg, +4

Journal of Biological Chemistry

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

Matthew S. Goldberg, Sheila M. Fleming, James Palacino, +13

Journal of Biological Chemistry

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

Clément Gautier, Tohru Kitada, Jie Shen

Proceedings of the National Academy of Sciences

Increased SensitivityMitophagyNeurodegenerative DiseasesMitochondrial FunctionBiochemistry +13

Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

Matthew S. Goldberg, Antonio Pisani, Marián Haburčák, +12

Neuron

GeneticsParkinson DiseaseNeurologyNeuroscienceNeurodegeneration +4

Impaired dopamine release and synaptic plasticity in the striatum of <i>PINK1</i> -deficient mice

Tohru Kitada, Antonio Pisani, Douglas R. Porter, +7

Proceedings of the National Academy of Sciences

Synaptic TransmissionNeurotransmitterSynaptic SignalingSocial SciencesDopaminergic Dysfunction +17

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice

Youren Tong, Hiroo Yamaguchi, Emilie Giaime, +4

Proceedings of the National Academy of Sciences

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

Filio Billia, Ludger Hauck, Filip Konečný, +3

Proceedings of the National Academy of Sciences

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

R. Jeremy Nichols, Nicolas Dzamko, Nicholas A. Morrice, +8

Biochemical Journal

Neurodegenerative DiseasesMitophagySignal Transduction14-3-3 BindingSignaling Pathway +13