Toxicokinetics

Toxicokinetics is the study of the kinetics of absorption, distribution, metabolism, and excretion of xenobiotics under conditions of toxicity evaluation.

10.4K

Publications

460.5K

Citations

34.6K

Authors

5.1K

Institutions

Publications per year

2017–2026

1.3K

Variants

Toxicokinetic

Parents

Clinical ToxicologyVeterinary Toxicology

Children

Dose ProportionalityDose-exposure RelationshipsMetabolite KineticsNonlinear ToxicokineticsPhysiologically Based Toxicokinetic ModelingPopulation ToxicokineticsProtein BindingRenal EliminationRepeated-dose KineticsRoute Of Exposure

Publications

10.4K

Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays

Martin A. Hamilton, Rosemarie C. Russo, Robert V. Thurston · Environmental Science & Technology · 1977 · 2.7K citations

Pharmacy, Toxicology, Environmental Toxicology +10

Half-Life of Serum Elimination of Perfluorooctanesulfonate,Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers

Geary W. Olsen, Jean M. Burris, David J. Ehresman et al. · Environmental Health Perspectives · 2007 · 2K citations · Full text

Pharmacy, Pharmacokinetics, Toxicology +13

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

Alan Poland, Edward Glover, Andrew S. Kende · Journal of Biological Chemistry · 1976 · 1.4K citations · Full text

Pharmacy, Pharmacology, Toxicology +17

The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis

Mahshid Ghasemi, Tyron Turnbull, Sonia Sebastian et al. · International Journal of Molecular Sciences · 2021 · 1.2K citations · Full text

Life Sciences, Biochemistry, Cancer Biology +17

Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration

Jun Wang, G ZHOU, Chunying Chen et al. · Toxicology Letters · 2006 · 1.2K citations

Pharmacy, Pharmacokinetics, Toxicology +8

1–5 of 10.4K

Authors

34.6K

LS
Linda S. Birnbaum
National Institute of Environmental Health Sciences, United States
65 publications · 3.5K citations
35
h-index
ME
Melvin E. Andersen
The Hamner Institutes for Health Sciences, United States
50 publications · 4.5K citations
33
h-index
RA
Roman Ashauer
University of York, United Kingdom
26 publications · 2.3K citations
24
h-index
HJ
Harvey J. Clewell
The Hamner Institutes for Health Sciences, United States
33 publications · 2.7K citations
23
h-index
JG
J. G. Filser
Institute of Groundwater Ecology, Germany
31 publications · 2.5K citations
23
h-index

1–5 of 34.6K

Institutions

5.1K

1–8 of 5.1K

Venues

Toxicology and Applied Pharmacology
TAAP · 495 publications · 25.2K citations
79
h-index
PubMed
Repository · 689 publications · 25.7K citations
73
h-index
Environmental Science & Technology
199 publications · 16.3K citations
70
h-index
Toxicological Sciences
261 publications · 15.1K citations
69
h-index
Environmental Health Perspectives
EHP · 196 publications · 15.3K citations
63
h-index

1–5

See also Toxicokinetics
Core Processes	Metabolism Absorption Studies Distribution Studies Excretion Biotransformation Protein Binding Hepatic Clearance Biodegradation
Mathematical Models	Whole-body Toxicokinetic Models One-compartment Models Two-compartment Models Nonautonomous Compartment Models Physiological Compartment Models
Influencing Factors	Route Of Exposure Physicochemical Properties Protein Binding Hepatic Intrinsic Clearance Agarose Gel Electrophoresis Single-nucleotide Polymorphisms
Dose Metrics	Steady-state Plasma Concentration Area Under The Curve Hepatic Intrinsic Clearance Tissue Concentration Partition Coefficient