Concepedia

Target Occupancy Modeling

Target Occupancy Modeling is a computational and pharmacological framework that quantifies the dynamic engagement between covalent drugs and their intended biological targets over time, distinguishing itself by integrating chemical reactivity, binding kinetics, and system-level biological feedback to predict the extent and duration of target inhibition within the context of Systems Pharmacodynamics.

34

Publications

2K

Citations

242

Authors

92

Institutions

Publications per year

2017–2026

18

Parents

Publications

34

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

James D. Vasta, Cesear Corona, Jennifer Wilkinson et al. · Cell chemical biology · 2017 · 293 citations · Full text

, , +14

Drug–Target Kinetics in Drug Discovery

Peter J. Tonge · ACS Chemical Neuroscience · 2017 · 289 citations · Full text

, , +17

How Many Hospital Beds?

Linda V. Green · INQUIRY The Journal of Health Care Organization Provision and Financing · 2002 · 204 citations · Full text

, , +16

Strategies for cutting hospital beds: the impact on patient service.

L V Green, Viet Anh Nguyen · PubMed · 2001 · 153 citations

, , +17

Mathematical modelling and simulation for planning critical care capacity*

A. X. Costa, S. Ridley, A. K. Shahani et al. · Anaesthesia · 2003 · 141 citations

, , +15

1–5 of 34

Authors

242

  1. WE
    Wilhelmus E. A. de Witte

    Centre for Human Drug Research, Netherlands

    3 publications · 62 citations

    3

    h-index

  2. GV
    Georges Vauquelin

    Vrije Universiteit Brussel, Belgium

    3 publications · 166 citations

    3

    h-index

  3. RE
    Richard E. Carson

    Yale University, United States

    4 publications · 152 citations

    3

    h-index

  4. EC
    Elizabeth C. M. de Lange

    Leiden University, Netherlands

    3 publications · 62 citations

    3

    h-index

  5. CS
    Cristian Salinas

    Imperial College London, United Kingdom

    2 publications · 35 citations

    2

    h-index

1–5 of 242

Institutions

92

  1. Columbia University

    New York, United States

    4 h-index

    20 publications

    699 citations

  2. Centre for Human Drug Research

    Leiden, The Netherlands

    3 h-index

    14 publications

    273 citations

  3. Yale University

    New Haven, United States

    3 h-index

    23 publications

    941 citations

  4. Vrije Universiteit Brussel

    Brussels, Belgium

    3 h-index

    3 publications

    166 citations

  5. Hammersmith Hospital

    London, United Kingdom

    2 h-index

    6 publications

    98 citations

  6. Stony Brook University

    Stony Brook, United States

    2 h-index

    10 publications

    910 citations

  7. University of Oxford

    Oxford, United Kingdom

    2 h-index

    3 publications

    601 citations

  8. GlaxoSmithKline (United Kingdom)

    London, United Kingdom

    2 h-index

    19 publications

    360 citations

1–8 of 92

Venues

  1. British Journal of Pharmacology

    BJP · 3 publications · 153 citations

    3

    h-index

  2. 2

    h-index

  3. CPT Pharmacometrics & Systems Pharmacology

    PSP · 2 publications · 53 citations

    2

    h-index

  4. Biological Psychiatry

    1 publications · 53 citations

    1

    h-index

  5. 1

    h-index

1–5