Peter J. Tonge

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

Sarah Kinnings, Nina Liu, N A Buchmeier et al. · PLoS Computational Biology · 2009 · 326 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the <i>Mycobacterium tuberculosis</i> enoyl reductase: Adduct affinity and drug resistance

Richa Rawat, Adrian Whitty, Peter J. Tonge · Proceedings of the National Academy of Sciences · 2003 · 323 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Drug–Target Kinetics in Drug Discovery

Peter J. Tonge · ACS Chemical Neuroscience · 2017 · 289 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Inhibition of InhA, the Enoyl Reductase from <i>Mycobacterium tuberculosis</i>, by Triclosan and Isoniazid

Sapan Parikh, Guoping Xiao, Peter J. Tonge · Biochemistry · 2000 · 237 citations

Life Sciences, Biochemistry, Pharmacology +14

High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of <i>Mycobacterium tuberculosis</i>

Todd J. Sullivan, J.J. Truglio, Melissa E. Boyne et al. · ACS Chemical Biology · 2006 · 233 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17