Concepedia

Target Deconvolution

Target Deconvolution is an experimental and computational strategy in chemical genomics that retrospectively identifies and validates the specific molecular targets (such as genes, proteins, or pathways) through which a bioactive small molecule produces an observed phenotype, thereby linking phenotypic screening hits to their mechanisms of action.

40

Publications

1.8K

Citations

323

Authors

128

Institutions

Publications per year

2017–2026

22

Parents

Children

Publications

40

TranSynergy: Mechanism-driven interpretable deep neural network for the synergistic prediction and pathway deconvolution of drug combinations

Qiao Liu, Lei Xie · PLoS Computational Biology · 2021 · 206 citations · Full text

, , +16

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes

Ilaria Piazza, Nigel Beaton, Roland Bruderer et al. · Nature Communications · 2020 · 180 citations · Full text

, , +14

Exploiting polypharmacology for drug target deconvolution

Taranjit S. Gujral, Leonid Peshkin, Marc W. Kirschner · Proceedings of the National Academy of Sciences · 2014 · 113 citations · Full text

, , +16

Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Severin Lechner, Martin Ian P. Malgapo, Christian Grätz et al. · Nature Chemical Biology · 2022 · 112 citations · Full text

, , +9

Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin

Amir Ata Saei, Hjalmar Gullberg, Pierre Sabatier et al. · Redox Biology · 2020 · 97 citations · Full text

, , +17

1–5 of 40

Authors

323

  1. RA
    Roman A. Zubarev

    Karolinska Institutet, Sweden

    4 publications · 225 citations

    4

    h-index

  2. JZ
    Junzhe Zhang

    Chinese Academy of Medical Sciences & Peking Union Medical College, China

    2 publications · 47 citations

    2

    h-index

  3. LG
    Liwei Gu

    Chinese Academy of Medical Sciences & Peking Union Medical College, China

    2 publications · 47 citations

    2

    h-index

  4. ZL
    Zhijie Li

    Southern University of Science and Technology, China

    2 publications · 47 citations

    2

    h-index

  5. LD
    Lingyun Dai

    Southern University of Science and Technology, China

    2 publications · 47 citations

    2

    h-index

1–5 of 323

Institutions

128

  1. Karolinska Institutet

    Stockholm, Sweden

    5 h-index

    35 publications

    2.7K citations

  2. Science for Life Laboratory

    Stockholm, Sweden

    4 h-index

    23 publications

    1.8K citations

  3. Sechenov University

    Moscow, Russia

    2 h-index

    2 publications

    141 citations

  4. Stockholm University

    Stockholm, Sweden

    2 h-index

    6 publications

    494 citations

  5. Southern Medical University

    Guangzhou, China

    2 h-index

    3 publications

    65 citations

  6. China Academy of Chinese Medical Sciences

    Beijing, China

    2 h-index

    12 publications

    238 citations

  7. Southern University of Science and Technology

    Shenzhen, China

    2 h-index

    11 publications

    259 citations

  8. AstraZeneca (Sweden)

    Södertälje, Sweden

    2 h-index

    6 publications

    207 citations

1–8 of 128

Venues

  1. Nature Communications

    4 publications · 371 citations

    4

    h-index

  2. Journal of Chemical Information and Modeling

    JCIM · 3 publications · 68 citations

    3

    h-index

  3. SLAS DISCOVERY

    3 publications · 85 citations

    3

    h-index

  4. Methods in molecular biology

    Book series · 4 publications · 100 citations

    3

    h-index

  5. ACS Infectious Diseases

    2 publications · 52 citations

    2

    h-index

1–5