Concepedia

Phenotypic Screening Deconvolution

Phenotypic Screening Deconvolution is a target deconvolution method that identifies the molecular targets of bioactive compounds discovered through phenotypic screening by integrating experimental and computational approaches to link observed cellular phenotypes to specific protein targets or pathways.

12

Publications

548

Citations

56

Authors

22

Institutions

Publications per year

2017–2026

4

Parents

Publications

12

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Nicole Kleinstreuer, Jian Yang, Ellen L. Berg et al. · Nature Biotechnology · 2014 · 209 citations

, , +16

BIGCHEM: Challenges and Opportunities for Big Data Analysis in Chemistry

Igor V. Tetko, Ola Engkvist, Uwe Koch et al. · Molecular Informatics · 2016 · 123 citations · Full text

, , +17

Building Predictive Models for Mechanism-of-Action Classification from Phenotypic Assay Data Sets

Ellen L. Berg, Jian Yang, Mark A. Polokoff · SLAS DISCOVERY · 2013 · 46 citations · Full text

, , +13

Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery

Fang Ye · Journal of Pharmacological and Toxicological Methods · 2013 · 38 citations

, , +10

Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens

Rui Zhong, Jimi Kim, Hyun Seok Kim et al. · Nucleic Acids Research · 2014 · 23 citations · Full text

, , +14

1–5 of 12

Authors

56

  1. OE
    Ola Engkvist

    AstraZeneca (Sweden), Sweden

    2 publications · 135 citations

    2

    h-index

  2. EL
    Ellen L. Berg

    Stanford University, United States

    2 publications · 255 citations

    2

    h-index

  3. JY
    Jian Yang

    Chinese Academy of Sciences, China

    2 publications · 255 citations

    2

    h-index

  4. MA
    Mark A. Polokoff

    United States Military Academy, United States

    2 publications · 255 citations

    2

    h-index

  5. JM
    Julio Martín

    GlaxoSmithKline (Spain), Spain

    1 publications · 18 citations

    1

    h-index

1–5 of 56

Institutions

22

  1. AstraZeneca (Sweden)

    Södertälje, Sweden

    2 h-index

    3 publications

    258 citations

  2. DiscoveRx (United States)

    Fremont, United States

    2 h-index

    6 publications

    765 citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    1 h-index

    1 publications

    23 citations

  4. Harold C. Simmons Comprehensive Cancer Center

    Dallas, United States

    1 h-index

    1 publications

    23 citations

  5. Corning (United States)

    Corning, United States

    1 h-index

    1 publications

    38 citations

  6. AbbVie (United States)

    North Chicago, United States

    1 h-index

    6 publications

    114 citations

  7. University of Bonn

    Bonn, Germany

    1 h-index

    3 publications

    42 citations

  8. Sanofi (United States)

    Bridgewater, United States

    1 h-index

    3 publications

    33 citations

1–8 of 22

Venues

  1. SLAS DISCOVERY

    3 publications · 77 citations

    3

    h-index

  2. Nature Biotechnology

    1 publications · 209 citations

    2

    h-index

  3. ACS Omega

    1 publications · 14 citations

    1

    h-index

  4. ACS Chemical Biology

    1 publications · 18 citations

    1

    h-index

  5. 1

    h-index

1–5