Lei Xie

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Michael P. Menden, Dennis Wang, Mike J. Mason et al. · Nature Communications · 2019 · 363 citations · Full text

Medicine, Oncology, Pharmacology +16

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

Sarah Kinnings, Nina Liu, N A Buchmeier et al. · PLoS Computational Biology · 2009 · 326 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

Mengjie Hu, Qiang Luo, Gulimiran Alitongbieke et al. · Molecular Cell · 2017 · 314 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16

Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors

Li Xie, Li Xie, Jerry Li et al. · PLoS Computational Biology · 2009 · 255 citations · Full text

Life Sciences, Pharmacology, Systems Biology +15

Detecting evolutionary relationships across existing fold space, using sequence order-independent profile–profile alignments

Lei Xie, Philip E. Bourne · Proceedings of the National Academy of Sciences · 2008 · 251 citations · Full text

Life Sciences, Bioinformatics, Evolutionary Biology +15