Lei Xie

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Michael P. Menden, Dennis Wang, Mike J. Mason et al. · Nature Communications · 2019 · 350 citations · Full text

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

Sarah Kinnings, Nina Liu, N A Buchmeier et al. · PLoS Computational Biology · 2009 · 323 citations · Full text

Drug Target, Bioorganic Chemistry, Tuberculosis Prevention +18

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

Mengjie Hu, Qiang Luo, Gulimiran Alitongbieke et al. · Molecular Cell · 2017 · 308 citations · Full text

Inflammation, Cell Autophagy, Mitophagy +12

Detecting evolutionary relationships across existing fold space, using sequence order-independent profile–profile alignments

Lei Xie, Philip E. Bourne · Proceedings of the National Academy of Sciences · 2008 · 249 citations · Full text

Structural Bioinformatics, Comparative Genomics, Genetics +24

A Machine Learning-Based Method To Improve Docking Scoring Functions and Its Application to Drug Repurposing

Sarah Kinnings, Nina Liu, Peter J. Tonge et al. · Journal of Chemical Information and Modeling · 2011 · 224 citations · Full text