Concepedia

Severin Lechner

SL

9

Publications

372

Citations

9

H-Index

2022

Active since

Affiliations

Technical University of Munich(Current)

German Cancer Research Center

Deutschen Konsortium für Translationale Krebsforschung

Heidelberg University

Klinikum rechts der Isar

Severin Lechner is an author at Technical University of Munich specializing in drug discovery, medicine, and pharmacology.

Top concepts

MedicinePharmacologyDrug DiscoveryBiochemistryNatural SciencesMolecular BiologyProteomicsCancer ResearchPharmacotherapyProtein Folding

Publications per year

2022–2024

9

Publications

9

Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Severin Lechner, Martin Ian P. Malgapo, Christian Grätz et al. · Nature Chemical Biology · 2022 · 104 citations · Full text

Drug Target, Biochemistry, Medicine +5

Decrypting drug actions and protein modifications by dose- and time-resolved proteomics

Jana Zecha, Florian Bayer, Svenja Wiechmann et al. · Science · 2023 · 98 citations · Full text

Drug Target, Chemoprevention Strategy, Kinase Inhibitors +22

Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout

Raphael R. Steimbach, Corey J. Herbst‐Gervasoni, Severin Lechner et al. · Journal of the American Chemical Society · 2022 · 39 citations · Full text

A region‐resolved proteomic map of the human brain enabled by high‐throughput proteomics

Johanna Tüshaus, Amirhossein Sakhteman, Severin Lechner et al. · The EMBO Journal · 2023 · 31 citations · Full text

Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics

Stephan Eckert, Nicola Berner, Karl Kramer et al. · Nature Biotechnology · 2024 · 30 citations · Full text

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