Concepedia

Affinity-based Target Identification

Affinity-Based Target Identification is a biochemical method that isolates and identifies cellular target proteins of bioactive small molecules through selective binding interactions mediated by affinity probes.

63

Publications

4.2K

Citations

403

Authors

149

Institutions

Publications per year

2017–2026

20

Parents

Publications

63

Target identification using drug affinity responsive target stability (DARTS)

Brett Lomenick, Rui Hao, Nao Jonai et al. · Proceedings of the National Academy of Sciences · 2009 · 1.1K citations · Full text

, , +13

Drug Affinity Responsive Target Stability (DARTS) for Small-Molecule Target Identification

Melody Y. Pai, Brett Lomenick, Heejun Hwang et al. · Methods in molecular biology · 2014 · 347 citations

, , +14

High-performance affinity beads for identifying drug receptors

Noriaki Shimizu, Kotaro Sugimoto, Jianwei Tang et al. · Nature Biotechnology · 2000 · 251 citations

, , +13

Discovering High-Affinity Ligands for Proteins

Philip J. Hajduk, Robert Meadows, Stephen W. Fesik · Science · 1997 · 238 citations

, , +14

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis

Shirit Einav, Doron Gerber, Paul D. Bryson et al. · Nature Biotechnology · 2008 · 230 citations · Full text

, , +12

1–5 of 63

Authors

403

  1. HK
    Haruma Kawaguchi

    Keio University, Japan

    4 publications · 296 citations

    4

    h-index

  2. MH
    Mamoru Hatakeyama

    Tokyo Institute of Technology, Japan

    4 publications · 296 citations

    4

    h-index

  3. SQ
    Shao Q. Yao

    National University of Singapore, Singapore

    4 publications · 164 citations

    4

    h-index

  4. HH
    Hiroshi Handa

    Tokyo Institute of Technology, Japan

    4 publications · 296 citations

    4

    h-index

  5. JH
    Jing Huang

    University of California, Los Angeles, United States

    3 publications · 1.6K citations

    3

    h-index

1–5 of 403

Institutions

149

  1. Tokyo Institute of Technology

    Tokyo, Japan

    5 h-index

    38 publications

    3.4K citations

  2. National University of Singapore

    Singapore, Singapore

    5 h-index

    18 publications

    723 citations

  3. Broad Institute

    Cambridge, United States

    3 h-index

    8 publications

    271 citations

  4. Université Bourgogne Franche-Comté

    Besançon, France

    3 h-index

    9 publications

    423 citations

  5. Keio University

    Tokyo, Japan

    3 h-index

    12 publications

    422 citations

  6. Harvard University

    Cambridge, United States

    3 h-index

    14 publications

    1.3K citations

  7. University of California, Los Angeles

    Los Angeles, United States

    3 h-index

    22 publications

    15.2K citations

  8. ShanghaiTech University

    Shanghai, China

    2 h-index

    13 publications

    585 citations

1–8 of 149

Venues

  1. Chemical Communications

    ChemComm · 7 publications · 297 citations

    7

    h-index

  2. PLoS ONE

    4 publications · 85 citations

    4

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 1.2K citations

    2

    h-index

  4. Chemistry - A European Journal

    2 publications · 104 citations

    2

    h-index

  5. 2

    h-index

1–5