Concepedia

Drug Affinity Responsive Target Stability (DARTS) for Small-Molecule Target Identification

Melody Y. Pai, Brett Lomenick, Heejun Hwang, Robert H. Schiestl, William H. McBride, Joseph A. Loo, Jing Huang

Methods in molecular biology · 2014 · 347 citations · 18 references

DOI

Concepts

References

18

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Daniel Martinez Molina, Rozbeh Jafari, Marina Ignatushchenko et al. · Science · 2013 · 2.2K citations

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Target identification using drug affinity responsive target stability (DARTS)

Brett Lomenick, Rui Hao, Nao Jonai et al. · Proceedings of the National Academy of Sciences · 2009 · 1.1K citations · Full text

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Comparative Proteomic Analysis of Eleven Common Cell Lines Reveals Ubiquitous but Varying Expression of Most Proteins

Tamar Geiger, Anja Wehner, Christoph Schaab et al. · Molecular & Cellular Proteomics · 2012 · 845 citations · Full text

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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

R Chin, Xudong Fu, Melody Y. Pai et al. · Nature · 2014 · 612 citations · Full text

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Defining the transcriptome and proteome in three functionally different human cell lines

Emma Lundberg, Linn Fagerberg, Daniel Klevebring et al. · Molecular Systems Biology · 2010 · 382 citations · Full text

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