The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

R Chin, Xudong Fu, Melody Y. Pai, +33

Nature

Lifespan ExtensionMetabolite α-Ketoglutarate ExtendsEnergy MetabolismMetabolic PathwaysBiochemistry +11

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

Xudong Fu, R Chin, Laurent Vergnes, +22

Cell Metabolism

Molecular PhysiologyOxysterolBiochemistryNatural SciencesCatabolism +3

Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors.

Jian‐Fang Gui, Hélène Tronchère, Sharon D. Chandler, +1

Proceedings of the National Academy of Sciences

Sr FamilyRna SplicingMolecular BiologySplicing VariantTranscriptional Regulation +14

The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site.

Xudong Fu, T Maniatis

Proceedings of the National Academy of Sciences

GeneticsRna SplicingMolecular BiologyMolecular GeneticsSplicing Variant +14

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N‐oxide‐generating pathway, modulates platelet responsiveness and thrombosis risk

Weifei Zhu, Jennifer A. Buffa, Z. Wang, +12

Journal of Thrombosis and Haemostasis

ThrombosisFlavin Monooxygenase 3Thrombosis RiskBiochemistryBlood Platelet +8

Stimulation of Hair Growth by Small Molecules that Activate Autophagy

Min Chai, Meisheng Jiang, Laurent Vergnes, +10

Cell Reports

Metabolic remodelling during early mouse embryo development

Jing Zhao, Ke Yao, Hua Yu, +23

Nature Metabolism

Developmental BiologyMorphogenesisMetabolic RegulationEmbryonic DevelopmentMetabolism +2

Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells

Xudong Fu, Xiaoji Wu, Mohamed Nadhir Djekidel, +1

Nature Cell Biology

ChromatinState TransitionCell LineageDevelopmental BiologyLineage Plasticity +10

A transcriptional roadmap for 2C-like–to–pluripotent state transition

Xudong Fu, Mohamed Nadhir Djekidel, Yi Zhang

Science Advances

Transcriptional RegulationSystems BiologyDevelopmental BiologyLineage PlasticityCell Lineage +13

MicroRNA-185 Targets SOCS3 to Inhibit Beta-Cell Dysfunction in Diabetes

Lidao Bao, Xudong Fu, Si Mingwen, +4

PLoS ONE

Socs3 SirnaInsulin SignalingMetabolic SyndromeMetabolic SignalingCell Signaling +15