Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Weifei Zhu, Jill C. Gregory, Elin Org, +15

Cell

InflammationThrombosisThrombopoiesisThrombosis RiskDysbiosis +8

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

Zeneng Wang, Adam Roberts, Jennifer A. Buffa, +14

Cell

DysbiosisMedicineLipid PeroxidationNon-lethal InhibitionBiotechnology +7

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Ina Nemet, Prasenjit Prasad Saha, Nilaksh Gupta, +16

Cell

InflammationGastrointestinal Peptide HormoneDysbiosisMedicinePhysiology +11

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

Adam Roberts, Xiaodong Gu, Jennifer A. Buffa, +22

Nature Medicine

InflammationThrombosisThrombopoiesisBlood PlateletMedicine +6

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

Jill C. Gregory, Jennifer A. Buffa, Elin Org, +9

Journal of Biological Chemistry

Gut Microbiota–Dependent Trimethylamine <i>N</i> -Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes

Arash Haghikia, Xinmin S. Li, Thomas Liman, +17

Arteriosclerosis Thrombosis and Vascular Biology

Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential

Sarah M. Skye, Weifei Zhu, Kymberleigh A. Romano, +12

Circulation Research

HIV protease inhibitors promote atherosclerotic lesion formation independent of dyslipidemia by increasing CD36-dependent cholesteryl ester accumulation in macrophages

James Dressman, Jeanie Kincer, Sergey V. Matveev, +9

Journal of Clinical Investigation

Vascular DiseaseHiv Protease InhibitorsImmunologyPathologyHyperlipidemia +16

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N‐oxide‐generating pathway, modulates platelet responsiveness and thrombosis risk

Weifei Zhu, Jennifer A. Buffa, Z. Wang, +12

Journal of Thrombosis and Haemostasis

ThrombosisFlavin Monooxygenase 3Thrombosis RiskBiochemistryBlood Platelet +8

HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI–dependent manner

Ming Gong, Melinda E. Wilson, Thomas H. Kelly, +10

Journal of Clinical Investigation