Concepedia

Super-enhancer Interactions

Super-Enhancer Interactions is a long-range chromatin interaction phenomenon in which clusters of enhancers with exceptionally high transcriptional coactivator density engage in spatially coordinated regulatory contacts with target genes, distinguishing them from typical enhancer-promoter interactions by their scale, stability, and functional impact on cell identity and disease-associated gene regulation.

168

Publications

19.4K

Citations

1.9K

Authors

557

Institutions

Publications per year

2017–2026

137

Parents

Publications

168

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Warren A. Whyte, David A. Orlando, Denes Hnisz et al. · Cell · 2013 · 4.3K citations · Full text

, , +16

Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma

Bjoern Chapuy, Michael R. McKeown, Charles Y. Lin et al. · Cancer Cell · 2013 · 766 citations · Full text

, , +17

Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

Jian‐Feng Xiang, Qing-Fei Yin, Tian Chen et al. · Cell Research · 2014 · 737 citations · Full text

, , +17

Neuroblastoma is composed of two super-enhancer-associated differentiation states

Tim van Groningen, Jan Köster, Linda J. Valentijn et al. · Nature Genetics · 2017 · 571 citations · Full text

, , +11

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

Henry E. Pelish, Brian B. Liau, I Niţulescu et al. · Nature · 2015 · 405 citations · Full text

, , +14

1–5 of 168

Authors

1.9K

  1. RA
    Richard A. Young

    Whitehead Institute for Biomedical Research, United States

    6 publications · 1.7K citations

    6

    h-index

  2. HP
    H. Phillip Koeffler

    Cedars-Sinai Medical Center, United States

    4 publications · 556 citations

    4

    h-index

  3. ZT
    Zhonghui Tang

    Jackson Laboratory, United States

    4 publications · 800 citations

    4

    h-index

  4. JE
    James E. Bradner

    Dana-Farber Cancer Institute, United States

    4 publications · 1.3K citations

    4

    h-index

  5. BM
    Biola M. Javierre

    Babraham Institute, United Kingdom

    3 publications · 201 citations

    3

    h-index

1–5 of 1.9K

Institutions

557

  1. Sun Yat-sen University

    Guangzhou, China

    13 h-index

    83 publications

    4K citations

  2. Dana-Farber Cancer Institute

    Boston, United States

    13 h-index

    57 publications

    18.7K citations

  3. National Institutes of Health

    Bethesda, United States

    12 h-index

    82 publications

    11.6K citations

  4. Harvard University

    Cambridge, United States

    11 h-index

    60 publications

    9.5K citations

  5. National Cancer Institute

    Bethesda, United States

    10 h-index

    35 publications

    4K citations

  6. Center for Cancer Research

    Bethesda, United States

    9 h-index

    31 publications

    4.8K citations

  7. National University of Singapore

    Singapore, Singapore

    8 h-index

    57 publications

    5.8K citations

  8. National University Cancer Institute, Singapore

    Singapore, Singapore

    8 h-index

    52 publications

    5.7K citations

1–8 of 557

Venues

  1. Nature Communications

    26 publications · 2.1K citations

    22

    h-index

  2. Nucleic Acids Research

    15 publications · 925 citations

    15

    h-index

  3. Cell Reports

    11 publications · 1.2K citations

    11

    h-index

  4. Cell

    5 publications · 5.3K citations

    5

    h-index

  5. Scientific Reports

    4 publications · 178 citations

    4

    h-index

1–5