Concepedia

Solution-phase Combinatorial Synthesis

Solution-Phase Combinatorial Synthesis is a method in combinatorial chemistry that enables the parallel synthesis of compound libraries in homogeneous reaction media, distinguished from solid-phase approaches by conducting reactions and intermediate purifications in liquid phase without the use of insoluble supports.

127

Publications

5.3K

Citations

445

Authors

134

Institutions

Publications per year

2017–2026

2

Parents

Publications

127

Modern Separation Techniques for the Efficient Workup in Organic Synthesis

Carl Christoph Tzschucke, Christian Märkert, Willi Bannwarth et al. · Angewandte Chemie International Edition · 2002 · 346 citations

, , +10

Polymer-Supported Quenching Reagents for Parallel Purification

Robert J. Booth, John C. Hodges · Journal of the American Chemical Society · 1997 · 265 citations

, , +14

Total Synthesis of Distamycin A and 2640 Analogues:  A Solution-Phase Combinatorial Approach to the Discovery of New, Bioactive DNA Binding Agents and Development of a Rapid, High-Throughput Screen for Determining Relative DNA Binding Affinity or DNA Binding Sequence Selectivity

Dale L. Boger, Brian E. Fink, Michael P. Hedrick · Journal of the American Chemical Society · 2000 · 179 citations

, , +17

Vanadium(III) chloride catalyzed Biginelli condensation: solution phase library generation of dihydropyrimidin-(2H)-ones

Gowravaram Sabitha, G. Sudhakar Reddy, K. Bhaskar Reddy et al. · Tetrahedron Letters · 2003 · 159 citations

, , +12

Novel Solution Phase Strategy for the Synthesis of Chemical Libraries Containing Small Organic Molecules

Soan Cheng, Daniel D. Comer, John P. Williams et al. · Journal of the American Chemical Society · 1996 · 153 citations

, , +17

1–5 of 127

Authors

445

  1. DL
    Dale L. Boger

    Scripps Research Institute, United States

    11 publications · 800 citations

    11

    h-index

  2. PD
    P. Dan Cook

    Ionis Pharmaceuticals (United States), United States

    5 publications · 184 citations

    5

    h-index

  3. HA
    Haoyun An

    Ionis Pharmaceuticals (United States), United States

    4 publications · 173 citations

    4

    h-index

  4. AG
    A. Ganesan

    University of Southampton, United Kingdom

    4 publications · 200 citations

    4

    h-index

  5. RS
    Richard Storer

    University of Oxford, United Kingdom

    3 publications · 170 citations

    3

    h-index

1–5 of 445

Institutions

134

  1. Scripps Research Institute

    San Diego, United States

    11 h-index

    33 publications

    2.6K citations

  2. Ionis Pharmaceuticals (United States)

    Carlsbad, United States

    5 h-index

    28 publications

    1.2K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    21 publications

    515 citations

  4. University of Hertfordshire

    Hatfield, United Kingdom

    3 h-index

    8 publications

    679 citations

  5. Tohoku University

    Sendai, Japan

    3 h-index

    12 publications

    277 citations

  6. Monsanto (United States)

    Creve Coeur, United States

    3 h-index

    10 publications

    470 citations

  7. SignalRx Pharmaceuticals (United States)

    San Diego, United States

    2 h-index

    12 publications

    1K citations

  8. University of Pittsburgh

    Pittsburgh, United States

    2 h-index

    5 publications

    214 citations

1–8 of 134

Venues

  1. Tetrahedron Letters

    23 publications · 940 citations

    17

    h-index

  2. Journal of Combinatorial Chemistry

    22 publications · 591 citations

    15

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    10 publications · 413 citations

    10

    h-index

  4. The Journal of Organic Chemistry

    JOC · 10 publications · 344 citations

    10

    h-index

  5. Journal of the American Chemical Society

    JACS · 6 publications · 831 citations

    6

    h-index

1–5