Concepedia

Scaffold Diversification

Scaffold Diversification is a synthetic strategy in combinatorial chemistry whereby a common core molecular scaffold is systematically modified—typically by varying attached substituents, ring systems, or linkers—to generate libraries of structurally diverse compounds while preserving the central framework.

1.1K

Publications

52.7K

Citations

4.5K

Authors

962

Institutions

Publications per year

2017–2026

550

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Publications

1.1K

C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

Joanna Wencel‐Delord, Frank Glorius · Nature Chemistry · 2013 · 2.4K citations

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Applications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds

James D. Sunderhaus, Stephen F. Martin · Chemistry - A European Journal · 2009 · 736 citations · Full text

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Recent advances in post-synthetic modification of metal–organic frameworks: New types and tandem reactions

Zheng Yin, Shuang Wan, Jian Yang et al. · Coordination Chemistry Reviews · 2017 · 583 citations

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From Noble Metal to Nobel Prize: Palladium‐Catalyzed Coupling Reactions as Key Methods in Organic Synthesis

Xiao‐Feng Wu, Pazhamalai Anbarasan, Helfried Neumann et al. · Angewandte Chemie International Edition · 2010 · 583 citations

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Strain-release amination

Ryan Gianatassio, Justin M. Lopchuk, Jie Wang et al. · Science · 2016 · 580 citations

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1–5 of 1.1K

Authors

4.5K

  1. FS
    Feng Shi

    Jiangsu Normal University, China

    21 publications · 1.6K citations

    19

    h-index

  2. DR
    David R. Spring

    University of Cambridge, United Kingdom

    12 publications · 596 citations

    12

    h-index

  3. MN
    Michaïl N. Elinson

    N.D. Zelinsky Institute of Organic Chemistry, Russia

    12 publications · 360 citations

    12

    h-index

  4. AN
    Adam Nelson

    University of Leeds, United Kingdom

    10 publications · 439 citations

    11

    h-index

  5. HL
    Hong Liu

    Shanghai Institute of Materia Medica, China

    8 publications · 219 citations

    9

    h-index

1–5 of 4.5K

Institutions

962

  1. Centre National de la Recherche Scientifique

    Paris, France

    27 h-index

    230 publications

    11.2K citations

  2. Jiangsu Normal University

    Xuzhou, China

    23 h-index

    147 publications

    9.1K citations

  3. Chinese Academy of Sciences

    Beijing, China

    22 h-index

    145 publications

    5.6K citations

  4. Shanghai Institute of Organic Chemistry

    Shanghai, China

    17 h-index

    59 publications

    3.1K citations

  5. Sichuan University

    Chengdu, China

    17 h-index

    98 publications

    4.3K citations

  6. TU Dortmund University

    Dortmund, Germany

    15 h-index

    52 publications

    2.7K citations

  7. Max Planck Institute of Molecular Physiology

    Dortmund, Germany

    15 h-index

    64 publications

    3.8K citations

  8. University of Cambridge

    Cambridge, United Kingdom

    15 h-index

    83 publications

    4.3K citations

1–8 of 962

Venues

  1. Organic Letters

    OL · 149 publications · 6.3K citations

    47

    h-index

  2. Angewandte Chemie International Edition

    72 publications · 5.7K citations

    46

    h-index

  3. Journal of the American Chemical Society

    JACS · 46 publications · 4.5K citations

    38

    h-index

  4. The Journal of Organic Chemistry

    JOC · 96 publications · 3.1K citations

    33

    h-index

  5. Chemical Communications

    ChemComm · 47 publications · 2.2K citations

    29

    h-index

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