Concepedia

Macrocycle Diversification

Macrocycle Diversification is a methodological framework in organic and medicinal chemistry that enables the systematic structural modification of macrocyclic scaffolds to expand chemical diversity and optimize biological activity, distinguished from related diversification strategies by its focus on ring-constrained architectures and their unique conformational and pharmacological properties.

1K

Publications

37.8K

Citations

3.6K

Authors

752

Institutions

Publications per year

2017–2026

182

Parents

Publications

1K

Synthesis of Medium-Sized Rings by the Ring-Closing Metathesis Reaction

Martin E. Maier · Angewandte Chemie International Edition · 2000 · 505 citations

, , +15

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

Robert W. Huigens, Robert W. Hicklin, Timothy A. Flood et al. · Nature Chemistry · 2013 · 315 citations

, , +16

Deconstructive diversification of cyclic amines

Jose B. Roque, Yusuke Kuroda, Lucas Göttemann et al. · Nature · 2018 · 291 citations · Full text

, , +11

Total Syntheses of Epothilones A and B

Dong‐Fang Meng, Peter Bertinato, Aaron Balog et al. · Journal of the American Chemical Society · 1997 · 260 citations

, , +15

A Switchable [2]Rotaxane Asymmetric Organocatalyst That Utilizes an Acyclic Chiral Secondary Amine

Víctor Blanco, David A. Leigh, Vanesa Marcos et al. · Journal of the American Chemical Society · 2014 · 205 citations · Full text

, , +14

1–5 of 1K

Authors

3.6K

  1. AB
    Amos B. Smith

    University of Pennsylvania, United States

    17 publications · 1K citations

    15

    h-index

  2. GP
    Gerald Pattenden

    University of Nottingham, United Kingdom

    13 publications · 414 citations

    13

    h-index

  3. SK
    Sambasivarao Kotha

    Indian Institute of Technology Bombay, India

    10 publications · 289 citations

    10

    h-index

  4. LA
    Leo A. Paquette

    The Ohio State University, United States

    10 publications · 341 citations

    10

    h-index

  5. LA
    Ludger A. Wessjohann

    Leibniz Institute of Plant Biochemistry, Germany

    10 publications · 536 citations

    10

    h-index

1–5 of 3.6K

Institutions

752

  1. Scripps Research Institute

    San Diego, United States

    22 h-index

    96 publications

    6.8K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    22 h-index

    154 publications

    4.6K citations

  3. University of Pennsylvania

    Philadelphia, United States

    17 h-index

    56 publications

    3.3K citations

  4. Chinese Academy of Sciences

    Beijing, China

    16 h-index

    83 publications

    2.9K citations

  5. Monell Chemical Senses Center

    Philadelphia, United States

    15 h-index

    63 publications

    3.9K citations

  6. Harvard University

    Cambridge, United States

    13 h-index

    45 publications

    2.1K citations

  7. University of Cambridge

    Cambridge, United Kingdom

    13 h-index

    78 publications

    2.6K citations

  8. Shanghai Institute of Organic Chemistry

    Shanghai, China

    13 h-index

    52 publications

    2.2K citations

1–8 of 752

Venues

  1. Journal of the American Chemical Society

    JACS · 66 publications · 5.8K citations

    52

    h-index

  2. Organic Letters

    OL · 187 publications · 6.9K citations

    47

    h-index

  3. Angewandte Chemie International Edition

    55 publications · 3.7K citations

    38

    h-index

  4. The Journal of Organic Chemistry

    JOC · 97 publications · 3.7K citations

    36

    h-index

  5. Tetrahedron Letters

    109 publications · 2.9K citations

    30

    h-index

1–5