Concepedia

Salt Bridge Engineering

Salt Bridge Engineering is a protein engineering strategy that belongs to the class of thermostability enhancement methods, specifically distinguished by the introduction or optimization of electrostatic interactions between oppositely charged amino acid residues to stabilize the three-dimensional structure of proteins under elevated temperatures.

24

Publications

1.3K

Citations

126

Authors

44

Institutions

Publications per year

2017–2026

6

Parents

Publications

24

Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis

Dao Pin Sun, Uwe H. Sauer, H. Nicholson et al. · Biochemistry · 1991 · 241 citations

, , +17

Controlling the Dissociation of Ligands from the Adenosine A <sub>2A</sub> Receptor through Modulation of Salt Bridge Strength

Elena Segala, Dong Guo, R.K. Cheng et al. · Journal of Medicinal Chemistry · 2016 · 192 citations · Full text

, , +17

Thermodynamic and Kinetic Stabilities of Complementary Double Helices Utilizing Amidinium–Carboxylate Salt Bridges

Hidekazu Yamada, Zong‐Quan Wu, Yoshio Furusho et al. · Journal of the American Chemical Society · 2012 · 96 citations

, , +17

Steric Hindrance as a Basis for Structure-Based Design of Selective Inhibitors of Protein-Tyrosine Phosphatases

Lars Iversen, Henrik Sune Andersen, Karin Möller et al. · Biochemistry · 2001 · 74 citations

, , +17

Less Unfavorable Salt Bridges on the Enzyme Surface Result in More Organic Cosolvent Resistance

Haiyang Cui, Lobna Eltoukhy, Lingling Zhang et al. · Angewandte Chemie International Edition · 2021 · 74 citations · Full text

, , +17

1–5 of 24

Authors

126

  1. AS
    Andrew S. Dixon

    University of Utah, United States

    1 publications · 33 citations

    1

    h-index

  2. CS
    Chuanqi Sun

    East China University of Science and Technology, China

    1 publications · 17 citations

    1

    h-index

  3. HR
    Henry R. Maun

    University of Freiburg, Germany

    1 publications · 47 citations

    1

    h-index

  4. MO
    M. Ottosen

    University of Copenhagen, Denmark

    1 publications · 23 citations

    1

    h-index

  5. AL
    Adelheid Löhle

    Boehringer Ingelheim (Germany), Germany

    1 publications · 13 citations

    1

    h-index

1–5 of 126

Institutions

44

  1. Procter & Gamble (United States)

    Cincinnati, United States

    1 h-index

    4 publications

    216 citations

  2. City of Hope

    Lancaster, United States

    1 h-index

    5 publications

    65 citations

  3. University of Michigan

    Ann Arbor, United States

    1 h-index

    1 publications

    23 citations

  4. Jiangnan University

    Wuxi, China

    1 h-index

    7 publications

    315 citations

  5. University of Groningen

    Groningen, The Netherlands

    1 h-index

    4 publications

    168 citations

  6. Angiogenesis Foundation

    Cambridge, United States

    1 h-index

    1 publications

    47 citations

  7. UPMC Hillman Cancer Center

    Pittsburgh, United States

    1 h-index

    2 publications

    92 citations

  8. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    1 h-index

    2 publications

    32 citations

1–8 of 44

Venues

  1. Biochemistry

    3 publications · 334 citations

    3

    h-index

  2. Journal of the American Chemical Society

    JACS · 2 publications · 168 citations

    2

    h-index

  3. 2

    h-index

  4. Protein Engineering Design and Selection

    PEDS · 1 publications · 54 citations

    1

    h-index

  5. Food Chemistry

    1 publications · 45 citations

    1

    h-index

1–5