H. Nicholson

Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding.

Brian W. Matthews, H. Nicholson, Wayne J. Becktel · Proceedings of the National Academy of Sciences · 1987 · 760 citations · Full text

Protein Assembly, Molecular Biology, Amino Acid Substitutions +16

Enhanced protein thermostability from designed mutations that interact with α-helix dipoles

H. Nicholson, Wayne J. Becktel, Brian W. Matthews · Nature · 1988 · 285 citations

Protein Chemistry, Protein Folding, Natural Sciences +10

Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis

Dao Pin Sun, Uwe H. Sauer, H. Nicholson et al. · Biochemistry · 1991 · 240 citations

Protein Assembly, Biochemistry, Protein Folding +14

Analysis of the interaction between charged side chains and the .alpha.-helix dipole using designed thermostable mutants of phage T4 lysozyme

H. Nicholson, David E. Anderson, S. Daopin et al. · Biochemistry · 1991 · 165 citations

Replacements of Pro ⁸⁶ in Phage T4 Lysozyme Extend an α-Helix But Do Not Alter Protein Stability

Tom Alber, Jeffrey A. Bell, Sun Daopin et al. · Science · 1988 · 131 citations

Protein Chemistry, Predicted Stabilities, Protein Function +14