Enzyme function prediction using contrastive learning

Tianhao Yu, Haiyang Cui, Jianan Canal Li, +3

Science

Machine LearningEnzyme CommissionBiostatisticsProteomicsEc Numbers +17

Machine learning-enabled retrobiosynthesis of molecules

Tianhao Yu, Aashutosh Girish Boob, Michael Volk, +3

Nature Catalysis

BiosynthesisEngineeringComputational BiologyMolecular BiologySynthetic Biology +3

Discovery and mechanism-guided engineering of BHET hydrolases for improved PET recycling and upcycling

Anni Li, Yijie Sheng, Haiyang Cui, +6

Nature Communications

Enzyme Hydration Determines Resistance in Organic Cosolvents

Haiyang Cui, Lingling Zhang, Lobna Eltoukhy, +5

ACS Catalysis

Os ResistanceBiosynthesisEnzyme Surface HydrationOrganic SolventsBiochemistry +11

Photoenzymatic enantioselective intermolecular radical hydroamination

Zhengyi Zhang, Jianqiang Feng, Chao Yang, +5

Nature Catalysis

EngineeringPhotochemistryMechanistic PhotochemistrySynthetic PhotochemistryPhotocatalysis +2

Directed Evolution of a Bacterial Laccase (CueO) for Enzymatic Biofuel Cells

Lingling Zhang, Haiyang Cui, Zhi Zou, +4

Angewandte Chemie International Edition

Computer‐Assisted Recombination (CompassR) Teaches us How to Recombine Beneficial Substitutions from Directed Evolution Campaigns

Haiyang Cui, Hao Cao, Haiying Cai, +3

Chemistry - A European Journal

How to Engineer Organic Solvent Resistant Enzymes: Insights from Combined Molecular Dynamics and Directed Evolution Study

Haiyang Cui, Tom H. J. Stadtmüller, Qianjia Jiang, +3

ChemCatChem

Proteinlipid InteractionEngineeringMolecular BiologyAnalytical UltracentrifugationMolecular Dynamics +19

Less Unfavorable Salt Bridges on the Enzyme Surface Result in More Organic Cosolvent Resistance

Haiyang Cui, Lobna Eltoukhy, Lingling Zhang, +4

Angewandte Chemie International Edition

E74 exhibits stage-specific hormonal regulation in the epidermis of the tobacco hornworm, manduca sexta

Geoffrey E Stilwell, Charles A. Nelson, John E. Weller, +4

Developmental Biology

BiologyStage-specific Hormonal RegulationDevelopmental BiologyPheromone BiochemistryManduca Sexta +7