Concepedia

Ring Bioisosterism

Ring Bioisosterism is a specialized form of bioisosterism in medicinal chemistry where the replacement of a cyclic structure with another ring system maintains similar biological activity due to comparable physicochemical and spatial properties.

65

Publications

3.2K

Citations

331

Authors

89

Institutions

Publications per year

2017–2026

16

Parents

Children

Publications

65

Photochemical Intermolecular [3σ + 2σ]-Cycloaddition for the Construction of Aminobicyclo[3.1.1]heptanes

Yongxiang Zheng, Weichen Huang, Roshan K. Dhungana et al. · Journal of the American Chemical Society · 2022 · 223 citations · Full text

, , +13

Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

Benjamin A. Chalmers, Hui Xing, Sevan D. Houston et al. · Angewandte Chemie International Edition · 2016 · 187 citations

, , +13

An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates

Yangyang Yang, Jet Tsien, Jonathan M. E. Hughes et al. · Nature Chemistry · 2021 · 181 citations · Full text

, , +11

The Most Common Chemical Replacements in Drug-Like Compounds

Robert P. Sheridan · Journal of Chemical Information and Computer Sciences · 2002 · 165 citations

, , +17

2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring

Aleksandr Denisenko, Pavel Garbuz, Nataliya M. Voloshchuk et al. · Nature Chemistry · 2023 · 160 citations · Full text

, , +17

1–5 of 65

Authors

331

  1. PK
    Pavel K. Mykhailiuk

    Enamine (Ukraine), Ukraine

    5 publications · 391 citations

    5

    h-index

  2. OS
    Oleh Shablykin

    Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar, Ukraine

    4 publications · 231 citations

    4

    h-index

  3. CP
    Cielo Pasay

    QIMR Berghofer Medical Research Institute, Australia

    3 publications · 269 citations

    3

    h-index

  4. JJ
    James J. De Voss

    The University of Queensland, Australia

    3 publications · 269 citations

    3

    h-index

  5. PB
    Petro Borysko

    Enamine (Ukraine), Ukraine

    3 publications · 259 citations

    3

    h-index

1–5 of 331

Institutions

89

  1. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    5 h-index

    13 publications

    1.4K citations

  2. Enamine (Ukraine)

    Kyiv, Ukraine

    5 h-index

    45 publications

    2.9K citations

  3. Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar

    Kyiv, Ukraine

    4 h-index

    5 publications

    320 citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    14 publications

    494 citations

  5. Novartis (Switzerland)

    Basel, Switzerland

    3 h-index

    5 publications

    169 citations

  6. QIMR Berghofer Medical Research Institute

    Brisbane, Australia

    3 h-index

    13 publications

    1.3K citations

  7. Novartis Institutes for BioMedical Research

    Basel, Switzerland

    3 h-index

    5 publications

    169 citations

  8. The University of Queensland

    Brisbane, Australia

    3 h-index

    29 publications

    2.2K citations

1–8 of 89

Venues

  1. Bioorganic & Medicinal Chemistry Letters

    7 publications · 188 citations

    7

    h-index

  2. Tetrahedron Letters

    5 publications · 86 citations

    5

    h-index

  3. Angewandte Chemie International Edition

    4 publications · 378 citations

    4

    h-index

  4. Tetrahedron

    4 publications · 63 citations

    4

    h-index

  5. European Journal of Medicinal Chemistry

    4 publications · 214 citations

    4

    h-index

1–5