Concepedia

Aromatic Ring Replacement

Aromatic Ring Replacement is a medicinal chemistry strategy within ring bioisosterism that involves substituting an aromatic ring with a non-aromatic cyclic or acyclic counterpart exhibiting comparable spatial, electronic, and physicochemical properties to maintain or modulate biological activity.

376

Publications

21.5K

Citations

1.9K

Authors

515

Institutions

Publications per year

2017–2026

43

Parents

Publications

376

A Chemically Functionalizable Nanoporous Material [Cu <sub>3</sub> (TMA) <sub>2</sub> (H <sub>2</sub> O) <sub>3</sub> ] <sub> <i>n</i> </sub>

S.S.-Y. Chui, S.M.F. Lo, J.P.H. Charmant et al. · Science · 1999 · 6K citations

, , +17

Estrogen Receptor-β Potency-Selective Ligands:  Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues

Marvin J. Meyers, Jun Sun, Kathryn E. Carlson et al. · Journal of Medicinal Chemistry · 2001 · 678 citations · Full text

, , +17

Br···O Complexes as Probes of Factors Affecting Halogen Bonding: Interactions of Bromobenzenes and Bromopyrimidines with Acetone

Kevin E. Riley, Jane S. Murray, Peter Politzer et al. · Journal of Chemical Theory and Computation · 2008 · 316 citations

, , +17

REACTIVITY OF SINGLET OXYGEN TOWARD AMINO ACIDS AND PEPTIDES

Albert Michaeli, Jehuda Feitelson · Photochemistry and Photobiology · 1994 · 285 citations

, , +15

Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons.

Alan S. Horn, Joseph T. Coyle, Solomon H. Snyder · PubMed · 1971 · 284 citations

, , +14

1–5 of 376

Authors

1.9K

  1. AM
    Alexandra M. Z. Slawin

    University of St Andrews, United Kingdom

    3 publications · 109 citations

    3

    h-index

  2. ML
    María López‐Iglesias

    Universidad de Oviedo, Spain

    3 publications · 77 citations

    3

    h-index

  3. RJ
    Raymond J. Bergeron

    University of Florida, United States

    3 publications · 86 citations

    3

    h-index

  4. JW
    Jan Wiegand

    University of Florida, United States

    3 publications · 86 citations

    3

    h-index

  5. FG
    Françoise Guéritte

    Institut de Chimie des Substances Naturelles, France

    3 publications · 66 citations

    3

    h-index

1–5 of 1.9K

Institutions

515

  1. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    81 publications

    3K citations

  2. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    5 h-index

    26 publications

    1.7K citations

  3. Institut de Chimie des Substances Naturelles

    Gif-sur-Yvette, France

    5 h-index

    27 publications

    882 citations

  4. University of Michigan

    Ann Arbor, United States

    5 h-index

    22 publications

    410 citations

  5. Ghent University

    Ghent, Belgium

    4 h-index

    18 publications

    441 citations

  6. University of Vienna

    Vienna, Austria

    4 h-index

    14 publications

    332 citations

  7. University of Florida

    Gainesville, United States

    4 h-index

    19 publications

    757 citations

  8. University of Kansas

    Lawrence, United States

    4 h-index

    16 publications

    347 citations

1–8 of 515

Venues

  1. Journal of Medicinal Chemistry

    67 publications · 4.3K citations

    34

    h-index

  2. The Journal of Organic Chemistry

    JOC · 20 publications · 599 citations

    15

    h-index

  3. Journal of the American Chemical Society

    JACS · 15 publications · 983 citations

    12

    h-index

  4. Tetrahedron Letters

    9 publications · 216 citations

    9

    h-index

  5. Biochemistry

    8 publications · 334 citations

    8

    h-index

1–5