Annulation Bioisosterism
Annulation Bioisosterism is a ring bioisosteric strategy in medicinal chemistry wherein the substitution of a cyclic structural motif with another ring system preserves biological activity through comparable spatial and electronic properties, differing from other bioisosterisms by specifically involving ring-forming transformations.
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Mohamed H. El‐Shershaby, Adel Ghiaty, Ashraf H. Bayoumi et al. · Bioorganic & Medicinal Chemistry · 2021 · 67 citations · Full text
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