Concepedia

Non-aromatic Ring Replacement

Non-Aromatic Ring Replacement is a ring bioisosteric strategy in medicinal chemistry wherein a non-aromatic ring system is substituted for another ring structure to maintain or modulate biological activity while altering physicochemical properties.

19

Publications

539

Citations

81

Authors

21

Institutions

Publications per year

2017–2026

3

Parents

Publications

19

Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase

Michel Maillard, Roy K. Hom, Timothy E. Benson et al. · Journal of Medicinal Chemistry · 2007 · 111 citations · Full text

, , +14

Structural Requirements for the Interaction of 91 Hydroxylated Polychlorinated Biphenyls with Estrogen and Thyroid Hormone Receptors

Sundaram Arulmozhiraja · Toxicological Sciences · 2004 · 99 citations

, , +16

Modifying the porphyrin core — a chemist's jigsaw

Lena Arnold, Kläus Müllen · Journal of Porphyrins and Phthalocyanines · 2011 · 48 citations

, , +9

Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents

Yizhou Dong, Qian Shi, Kyoko Nakagawa‐Goto et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 31 citations

, , +10

The conformation of non-aromatic ring compounds. XVI. The crystal structure of 2β,3α-dichloro-5α-cholestane (modification β) at –120°C

H. J. Geise, C. Romers, E. W. M. Rutten · Acta Crystallographica · 1966 · 28 citations · Full text

, , +12

1–5 of 19

Authors

81

  1. CR
    C. Romers

    Leiden University, Netherlands

    4 publications · 81 citations

    4

    h-index

  2. BA
    B. Adinarayana

    National Institute of Science Education and Research, India

    2 publications · 48 citations

    2

    h-index

  3. MD
    Mainak Das

    National Institute of Science Education and Research, India

    2 publications · 48 citations

    2

    h-index

  4. HJ
    H. J. Geise

    University of Antwerp, Belgium

    2 publications · 42 citations

    2

    h-index

  5. AS
    A. Srinivasan

    National Institute of Science Education and Research, India

    2 publications · 48 citations

    2

    h-index

1–5 of 81

Institutions

21

  1. National Institute of Science Education and Research

    Bhubaneswar, India

    2 h-index

    8 publications

    188 citations

  2. Stanford University

    Stanford, United States

    2 h-index

    7 publications

    76 citations

  3. National Institute for Interdisciplinary Science and Technology

    Thiruvananthapuram, India

    1 h-index

    1 publications

    26 citations

  4. Max Planck Institute for Polymer Research

    Mainz, Germany

    1 h-index

    2 publications

    96 citations

  5. Laboratoire de Chimie

    Lyon, France

    1 h-index

    4 publications

    52 citations

  6. Daegu-Gyeongbuk Medical Innovation Foundation

    Daegu, South Korea

    1 h-index

    2 publications

    30 citations

  7. Korea Institute of Science and Technology

    Seoul, South Korea

    1 h-index

    2 publications

    30 citations

  8. National Institute for Environmental Studies

    Tsukuba, Japan

    1 h-index

    1 publications

    99 citations

1–8 of 21

Venues

  1. Tetrahedron Letters

    4 publications · 44 citations

    4

    h-index

  2. Acta Crystallographica

    3 publications · 70 citations

    3

    h-index

  3. Journal of Medicinal Chemistry

    2 publications · 128 citations

    2

    h-index

  4. International Journal of Molecular Sciences

    IJMS · 1 publications · 15 citations

    1

    h-index

  5. Bioorganic & Medicinal Chemistry Letters

    1 publications · 31 citations

    1

    h-index

1–5