Concepedia

Proteolytic Processing Of Caspase-9

Proteolytic Processing of Caspase-9 is a biochemical mechanism involving the site-specific cleavage of pro-caspase-9 into its active subunits within the apoptosome, enabling the initiation of caspase cascade during intrinsic apoptosis.

352

Publications

48.8K

Citations

1.8K

Authors

593

Institutions

Publications per year

2017–2026

29

Parents

Publications

352

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Peng Li, Deepak Nijhawan, I. Imawati Budihardjo et al. · Cell · 1997 · 7.3K citations · Full text

, , +17

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

Michael H. Cardone, Natalie Roy, Henning R. Stennicke et al. · Science · 1998 · 3.1K citations

, , +17

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

Keisuke Kuida, Tarik F. Haydar, Chia‐Yi Kuan et al. · Cell · 1998 · 1.6K citations · Full text

, , +15

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

Helen M. Beere, Beni B. Wolf, Kelvin Cain et al. · Nature Cell Biology · 2000 · 1.5K citations

, , +16

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

Razqallah Hakem, Anne Hakem, Gordon S. Duncan et al. · Cell · 1998 · 1.3K citations · Full text

, , +16

1–5 of 352

Authors

1.8K

  1. JC
    John C. Reed

    Sanford Burnham Prebys Medical Discovery Institute, United States

    11 publications · 4.6K citations

    11

    h-index

  2. GS
    Guy S. Salvesen

    Sanford Burnham Prebys Medical Discovery Institute, United States

    9 publications · 4.4K citations

    9

    h-index

  3. SM
    Srinivasa M. Srinivasula

    Thomas Jefferson University, United States

    8 publications · 10.3K citations

    8

    h-index

  4. KK
    Keisuke Kuida

    Vertex Pharmaceuticals (United States), United States

    7 publications · 2.9K citations

    7

    h-index

  5. YS
    Yigong Shi

    Tsinghua University, China

    6 publications · 1.6K citations

    6

    h-index

1–5 of 1.8K

Institutions

593

  1. Sanford Burnham Prebys Medical Discovery Institute

    La Jolla, United States

    17 h-index

    69 publications

    32.8K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    39 publications

    3.3K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    17 publications

    32.5K citations

  4. Inserm

    Paris, France

    8 h-index

    38 publications

    1.1K citations

  5. Vertex Pharmaceuticals (United States)

    Boston, United States

    8 h-index

    10 publications

    6.2K citations

  6. Harvard University

    Cambridge, United States

    7 h-index

    31 publications

    5K citations

  7. Baylor College of Medicine

    Houston, United States

    7 h-index

    34 publications

    8.3K citations

  8. The University of Texas MD Anderson Cancer Center

    Houston, United States

    6 h-index

    16 publications

    1.4K citations

1–8 of 593

Venues

  1. Journal of Biological Chemistry

    JBC · 49 publications · 7.2K citations

    43

    h-index

  2. Cell Death and Differentiation

    CDD · 17 publications · 2K citations

    16

    h-index

  3. PubMed

    Repository · 15 publications · 1.6K citations

    15

    h-index

  4. APOPTOSIS

    8 publications · 258 citations

    8

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 7 publications · 469 citations

    7

    h-index

1–5