Concepedia

Protease Kinetics

Protease Kinetics is a quantitative framework that characterizes the catalytic mechanisms and reaction rates of proteolytic enzymes, distinguishing it from other enzymatic studies by focusing specifically on the temporal dynamics and substrate specificity of peptide bond hydrolysis.

1.1K

Publications

53.8K

Citations

3.5K

Authors

982

Institutions

Publications per year

2017–2026

111

Parents

Publications

1.1K

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

Linlin Zhang, Daizong Lin, Xinyuanyuan Sun et al. · Science · 2020 · 3.4K citations · Full text

, , +15

Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency

Rachel B. Kapust, József Tőzsér, Jeffrey D. Fox et al. · Protein Engineering Design and Selection · 2001 · 879 citations · Full text

, , +17

Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.

Kiichiro Nakajima, James C. Powers, Bonnie M. Ashe et al. · Journal of Biological Chemistry · 1979 · 595 citations · Full text

, , +17

Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

Jennifer L. Harris, Bradley J. Backes, Francesco Leonetti et al. · Proceedings of the National Academy of Sciences · 2000 · 542 citations

, , +17

Rates of Uncatalyzed Peptide Bond Hydrolysis in Neutral Solution and the Transition State Affinities of Proteases

Anna Radzicka, Richard Wolfenden · Journal of the American Chemical Society · 1996 · 483 citations

, , +16

1–5 of 1.1K

Authors

3.5K

  1. KO
    Kōhei Oda

    Kyoto Institute of Technology, Japan

    10 publications · 185 citations

    10

    h-index

  2. NM
    Norman M. Schechter

    University of Pennsylvania, United States

    9 publications · 498 citations

    9

    h-index

  3. JM
    John M. Louis

    National Institutes of Health, United States

    9 publications · 517 citations

    9

    h-index

  4. HJ
    Hans‐Dieter Jakubke

    Leipzig University, Germany

    9 publications · 458 citations

    9

    h-index

  5. DA
    David A. Agard

    University of California, San Francisco, United States

    8 publications · 517 citations

    8

    h-index

1–5 of 3.5K

Institutions

982

  1. National Institutes of Health

    Bethesda, United States

    19 h-index

    68 publications

    7.6K citations

  2. University of California, San Francisco

    San Francisco, United States

    14 h-index

    40 publications

    6.7K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    14 h-index

    32 publications

    2.3K citations

  4. The University of Tokyo

    Tokyo, Japan

    13 h-index

    46 publications

    1.8K citations

  5. Leipzig University

    Leipzig, Germany

    13 h-index

    43 publications

    1.7K citations

  6. University of Pennsylvania

    Philadelphia, United States

    12 h-index

    46 publications

    2.1K citations

  7. Kyoto University

    Kyoto, Japan

    11 h-index

    32 publications

    1.2K citations

  8. Osaka Prefecture University

    Sakai, Japan

    10 h-index

    37 publications

    880 citations

1–8 of 982

Venues

  1. Journal of Biological Chemistry

    JBC · 105 publications · 7.2K citations

    49

    h-index

  2. Biochemistry

    103 publications · 4.9K citations

    43

    h-index

  3. European Journal of Biochemistry

    EJB · 54 publications · 2.7K citations

    28

    h-index

  4. Biochemical Journal

    BJ · 42 publications · 1.9K citations

    25

    h-index

  5. The Journal of Biochemistry

    JB · 34 publications · 1.3K citations

    23

    h-index

1–5