Xinyuanyuan Sun

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

Linlin Zhang, Daizong Lin, Xinyuanyuan Sun et al. · Science · 2020 · 3.4K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

Sebastian Günther, Sebastian Günther, P. Reinke et al. · Science · 2021 · 366 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +14

SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

Wioletta Rut, Katarzyna Groborz, Linlin Zhang et al. · Nature Chemical Biology · 2020 · 328 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

Mikołaj Żmudziński, Wioletta Rut, Kamila Olech et al. · Scientific Reports · 2023 · 43 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PL ^pro and M ^pro in in vitro studies

Mikołaj Żmudziński, Wioletta Rut, Kamila Olech et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 37 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17