James C. Powers

Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.

Kiichiro Nakajima, James C. Powers, Bonnie M. Ashe et al. · Journal of Biological Chemistry · 1979 · 595 citations · Full text

Protein Assembly, Immunology, Peptide Substrates +17

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

L Shi, Chih Min Kam, James C. Powers et al. · The Journal of Experimental Medicine · 1992 · 441 citations · Full text

Apoptosis, Immunology, Cell Death +20

Sensitive substrates for human leukocyte and porcine pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases

Mario J. Castillo, Kiichiro Nakajima, Morris Zimmerman et al. · Analytical Biochemistry · 1979 · 268 citations

Biochemistry, Sensitive Substrates, Medicine +10

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

Shirin Arastu‐Kapur, Elizabeth L. Ponder, Urša Pečar Fonović et al. · Nature Chemical Biology · 2008 · 256 citations

Biochemistry, Medicine, Natural Sciences +11

Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor

J. Wade Harper, Keiji Hemmi, James C. Powers · Biochemistry · 1985 · 229 citations