Concepedia

Phosphorothioate Modification

Phosphorothioate Modification is a chemical nucleic acid modification in which one of the non-bridging oxygen atoms in the phosphate backbone is substituted with a sulfur atom, thereby conferring nuclease resistance and enhanced binding affinity.

653

Publications

37.8K

Citations

2.6K

Authors

665

Institutions

Publications per year

2017–2026

123

Parents

Publications

653

The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA

W. John Taylor, Johann Ott, Fritz Eckstein · Nucleic Acids Research · 1985 · 848 citations · Full text

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Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

Brett P. Monia, Elena A. Lesnik, C. Gonzalez et al. · Journal of Biological Chemistry · 1993 · 770 citations · Full text

, , +16

Inhibition of restriction endonuclease Nel I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis

Kay L. Nakamaye, Fritz Eckstein · Nucleic Acids Research · 1986 · 553 citations · Full text

, , +15

RNA Interference in Mammalian Cells by Chemically-Modified RNA

Dwaine A. Braasch, Susan E. Jensen, Yinghui Liu et al. · Biochemistry · 2003 · 528 citations

, , +16

Specificity, duplex degradation and subcellular localization of antagomirs

Jan Krützfeldt, Satoru Kuwajima, Ravi Braich et al. · Nucleic Acids Research · 2007 · 454 citations · Full text

, , +17

1–5 of 653

Authors

2.6K

  1. ST
    Stanley T. Crooke

    Ionis Pharmaceuticals (United States), United States

    24 publications · 2.1K citations

    21

    h-index

  2. XL
    Xue‐hai Liang

    Ionis Pharmaceuticals (United States), United States

    21 publications · 1.8K citations

    19

    h-index

  3. PP
    Punit P. Seth

    Ionis Pharmaceuticals (United States), United States

    18 publications · 1.3K citations

    17

    h-index

  4. ZD
    Zixin Deng

    Shanghai Jiao Tong University, China

    19 publications · 916 citations

    16

    h-index

  5. FE
    Fritz Eckstein

    Max Planck Institute of Experimental Medicine, Germany

    15 publications · 2.9K citations

    15

    h-index

1–5 of 2.6K

Institutions

665

  1. Ionis Pharmaceuticals (United States)

    Carlsbad, United States

    44 h-index

    405 publications

    41.8K citations

  2. Shanghai Jiao Tong University

    Shanghai, China

    18 h-index

    147 publications

    7.8K citations

  3. Max Planck Institute of Experimental Medicine

    Göttingen, Germany

    15 h-index

    35 publications

    7.3K citations

  4. Polish Academy of Sciences

    Warsaw, Poland

    15 h-index

    84 publications

    3.5K citations

  5. Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

    Lodz, Poland

    15 h-index

    80 publications

    3.4K citations

  6. Wuhan University

    Wuhan, China

    12 h-index

    109 publications

    3.8K citations

  7. Tsinghua University

    Beijing, China

    10 h-index

    33 publications

    1.3K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    29 publications

    713 citations

1–8 of 665

Venues

  1. Nucleic Acids Research

    114 publications · 11.1K citations

    58

    h-index

  2. Biochemistry

    28 publications · 1.9K citations

    22

    h-index

  3. Journal of Biological Chemistry

    JBC · 23 publications · 2.3K citations

    19

    h-index

  4. Journal of the American Chemical Society

    JACS · 20 publications · 1.3K citations

    19

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 18 publications · 2K citations

    17

    h-index

1–5