Fritz Eckstein

The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA

W. John Taylor, Johann Ott, Fritz Eckstein · Nucleic Acids Research · 1985 · 848 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Inhibition of restriction endonuclease Nel I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis

Kay L. Nakamaye, Fritz Eckstein · Nucleic Acids Research · 1986 · 553 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

Wolfgang A. Pieken, David B. Olsen, Fritz Benseler et al. · Science · 1991 · 469 citations

Life Sciences, Biochemistry, Molecular Biology +17

Rapid and efficient synthesis of nucleoside 5'-0-(1-thiotriphosphates), 5'-triphosphates and 2',3'-cyclophosphorothioates using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one

János Ludwig, Fritz Eckstein · The Journal of Organic Chemistry · 1989 · 376 citations

Natural Sciences, Biochemistry, Chemistry +5

5′–3′ Exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis

Jon R. Sayers, Walter Schmidt, Fritz Eckstein · Nucleic Acids Research · 1988 · 327 citations · Full text

Life Sciences, Genetics, Molecular Biology +14