János Ludwig

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Katalin Karikó, Hiromi Muramatsu, Frank A. Welsh et al. · Molecular Therapy · 2008 · 1.9K citations · Full text

Life Sciences, Immunology, Molecular Biology +17

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Andrea Ablasser, Marion Goldeck, Taner Cavlar et al. · Nature · 2013 · 1.6K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Katalin Karikó, Hiromi Muramatsu, János Ludwig et al. · Nucleic Acids Research · 2011 · 884 citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

Martin Schlee, Andreas Roth, Veit Hornung et al. · Immunity · 2009 · 783 citations · Full text

Life Sciences, Biology, Molecular Biology +12

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

Delphine Goubau, Martin Schlee, Safia Deddouche et al. · Nature · 2014 · 561 citations

Life Sciences, Immunology, Molecular Biology +14