Pharmacophore-Based Selectivity Analysis is a computational method that identifies and characterizes the key pharmacophoric features responsible for differential biological activity across a series of structurally related compounds by mapping their spatial and chemical complementarity to specific target subtypes or off-targets.
59
Publications
6.9K
Citations
374
Authors
123
Institutions
Publications per year
2017–2026
14
Parents
Publications
59
A quantitative analysis of kinase inhibitor selectivity
Mazen W. Karaman, Sanna Herrgård, Daniel K. Treiber et al. · Nature Biotechnology · 2008 · 2.4K citations
Comprehensive analysis of kinase inhibitor selectivity
Mindy I. Davis, Jeremy P. Hunt, Sanna Herrgård et al. · Nature Biotechnology · 2011 · 2.4K citations · Full text
Functional selectivity of GPCR-directed drug action through location bias
Roshanak Irannejad, Veronica Pessino, Delphine Mika et al. · Nature Chemical Biology · 2017 · 244 citations · Full text
Type-specific Regulation of Adenylyl Cyclase
Takeshi Onda, Yoko Hashimoto, Masashi Nagai et al. · Journal of Biological Chemistry · 2001 · 114 citations · Full text
Pharmacy, Biochemistry, Pharmacology +16
Martin Winn, Thomas W von Geldern, Terry J. Opgenorth et al. · Journal of Medicinal Chemistry · 1996 · 113 citations · Full text
1–5 of 59
Authors
374
- MIMindy I. Davis
National Center for Advancing Translational Sciences, United States
2 publications · 4.8K citations
2
h-index
- JB
2
h-index
- PC
2
h-index
- PPPatrick P. Zarrinkar
Massachusetts Institute of Technology, United States
2 publications · 4.8K citations
2
h-index
- PM
2
h-index
1–5 of 374
Institutions
123
University of Bonn
Bonn, Germany
3 h-index
8 publications
177 citations
China Pharmaceutical University
Nanjing, China
3 h-index
12 publications
239 citations
University of Catania
Catania, Italy
2 h-index
5 publications
171 citations
National Institutes of Health
Bethesda, United States
2 h-index
9 publications
14.4K citations
National Cancer Institute
Bethesda, United States
2 h-index
10 publications
125 citations
Ankara University
Ankara, Türkiye
2 h-index
5 publications
423 citations
University of Genoa
Genoa, Italy
2 h-index
6 publications
126 citations
Center for Cancer Research
Bethesda, United States
2 h-index
10 publications
125 citations
1–8 of 123
Venues
- Bioorganic & Medicinal Chemistry Letters
9 publications · 341 citations
9
h-index
- Journal of Medicinal Chemistry
5 publications · 274 citations
5
h-index
- European Journal of Medicinal Chemistry
5 publications · 202 citations
5
h-index
- Bioorganic & Medicinal Chemistry
3 publications · 55 citations
3
h-index
- Journal of Chemical Information and Modeling
JCIM · 3 publications · 90 citations
3
h-index
1–5