Concepedia

Perforin Pathways

Perforin Pathways is a cytolytic mechanism in the immune system that, as a distinct molecular pathway within antitumor T cell responses, enables cytotoxic T lymphocytes to induce target tumor cell apoptosis through the pore-forming action of perforin and subsequent granzyme delivery.

592

Publications

48.6K

Citations

3.3K

Authors

949

Institutions

Publications per year

2017–2026

61

Parents

Publications

592

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

David Kägi, Birgit Ledermann, Kurt Bürki et al. · Nature · 1994 · 1.8K citations

, , +15

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

David Kägi, Françoise Vignaux, Birgit Ledermann et al. · Science · 1994 · 1.5K citations

, , +14

Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis

Susan E. Stepp, Rémi Dufourcq-Lagelouse, Françoise Le Deist et al. · Science · 1999 · 1.2K citations

, , +15

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

Bente Lowin, Michael Hahne, Chantal Mattmann et al. · Nature · 1994 · 1.1K citations

, , +10

Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

William J. Grossman, James Verbsky, Winfried Barchet et al. · Immunity · 2004 · 999 citations

, , +15

1–5 of 592

Authors

3.3K

  1. JA
    Joseph A. Trapani

    Peter MacCallum Cancer Centre, Australia

    28 publications · 2.6K citations

    23

    h-index

  2. ER
    Eckhard R. Podack

    University of Miami, United States

    22 publications · 3K citations

    18

    h-index

  3. MJ
    Mark J. Smyth

    Peter MacCallum Cancer Centre, Australia

    18 publications · 2.7K citations

    16

    h-index

  4. HY
    Hideo Yagita∥

    Juntendo University, Japan

    15 publications · 1.2K citations

    14

    h-index

  5. IV
    Ilia Voskoboinik

    Peter MacCallum Cancer Centre, Australia

    15 publications · 1.4K citations

    14

    h-index

1–5 of 3.3K

Institutions

949

  1. Peter MacCallum Cancer Centre

    Melbourne, Australia

    24 h-index

    125 publications

    13.6K citations

  2. Inserm

    Paris, France

    21 h-index

    129 publications

    18.7K citations

  3. University of Miami

    Coral Gables, United States

    20 h-index

    71 publications

    6.8K citations

  4. The University of Melbourne

    Melbourne, Australia

    19 h-index

    73 publications

    6.2K citations

  5. Juntendo University

    Tokyo, Japan

    15 h-index

    39 publications

    4.1K citations

  6. National Institutes of Health

    Bethesda, United States

    15 h-index

    70 publications

    13.8K citations

  7. National Cancer Institute

    Bethesda, United States

    14 h-index

    35 publications

    3K citations

  8. Harvard University

    Cambridge, United States

    14 h-index

    54 publications

    6K citations

1–8 of 949

Venues

  1. The Journal of Immunology

    JI · 71 publications · 6.2K citations

    46

    h-index

  2. Blood

    38 publications · 4K citations

    31

    h-index

  3. PubMed

    Repository · 26 publications · 1.1K citations

    20

    h-index

  4. European Journal of Immunology

    EJI · 14 publications · 1.2K citations

    13

    h-index

  5. Immunity

    13 publications · 3.9K citations

    13

    h-index

1–5