Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

Embryonic Stem Cell, Induced Pluripotent Stem Cell, Developmental Biology +9

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Knockout Mouse, Embryonic Stem Cell, Lineage Plasticity +12

Immune Response in Mice that Lack the Interferon-γ Receptor

Sui Huang, Wiljan Hendriks, Alana Althage et al. · Science · 1993 · 1.6K citations · Full text

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

Stephen Cobbold, A. Jayasuriya, Anthony A. Nash et al. · Nature · 1984 · 874 citations

Cell Therapy, Autoimmune Disease, Allergy +10

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

Éric Rouvier, M F Luciani, Pierre Golstein · The Journal of Experimental Medicine · 1993 · 795 citations · Full text

T-regulatory Cell, Apoptosis, Immunology +16