Concepedia

Pathway Synergy

Pathway Synergy is a biological phenomenon in which two or more signaling pathways interact in a non-additive manner to produce a coordinated cellular response that exceeds the sum of their individual effects, thereby enhancing signal transduction efficiency or functional outcomes.

10

Publications

847

Citations

80

Authors

42

Institutions

Publications per year

2017–2026

4

Parents

Publications

10

Regulation through the Secondary Channel—Structural Framework for ppGpp-DksA Synergism during Transcription

Anna Perederina, Vladimir Svetlov, Marina N. Vassylyeva et al. · Cell · 2004 · 358 citations · Full text

, , +11

Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation

Xinshou Ouyang, Hideo Negishi, Rie Takeda et al. · Biochemical and Biophysical Research Communications · 2007 · 112 citations

, , +11

Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia

Oliver M. Dovey, Jonathan Cooper, Annalisa Mupo et al. · Blood · 2017 · 97 citations · Full text

, , +15

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

Matthew J. Sale, Emma Minihane, Noel R. Monks et al. · Nature Communications · 2019 · 73 citations · Full text

, , +17

Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells

Yan Fu, Trevor Glaros, Meng Zhu et al. · PLoS Computational Biology · 2012 · 62 citations · Full text

, , +16

1–5 of 10

Authors

80

  1. MK
    Meggan K. Bayer

    St. Louis Children's Hospital, United States

    2 publications · 81 citations

    2

    h-index

  2. JF
    J. Fontan

    Université Toulouse III - Paul Sabatier, France

    2 publications · 81 citations

    2

    h-index

  3. MC
    Mara Chavolla-Calderón

    St. Louis Children's Hospital, United States

    2 publications · 81 citations

    2

    h-index

  4. KY
    Kosuke Yusa

    Wellcome Sanger Institute, United Kingdom

    1 publications · 97 citations

    1

    h-index

  5. JR
    Jonathan R. Dry

    AstraZeneca (United States), United States

    1 publications · 73 citations

    1

    h-index

1–5 of 80

Institutions

42

  1. The University of Tokyo

    Tokyo, Japan

    2 h-index

    6 publications

    918 citations

  2. St. Louis Children's Hospital

    St Louis, United States

    2 h-index

    2 publications

    81 citations

  3. Universidad de Zaragoza

    Zaragoza, Spain

    1 h-index

    1 publications

    21 citations

  4. Queen Elizabeth II Medical Centre

    Nedlands, Australia

    1 h-index

    1 publications

    97 citations

  5. Allen Institute for Brain Science

    Seattle, United States

    1 h-index

    1 publications

    23 citations

  6. National Institutes of Health

    Bethesda, United States

    1 h-index

    1 publications

    21 citations

  7. Cardiff University

    Cardiff, United Kingdom

    1 h-index

    1 publications

    97 citations

  8. Clemson University

    Clemson, United States

    1 h-index

    1 publications

    62 citations

1–8 of 42

Venues

  1. Journal of Clinical Investigation

    JCI · 2 publications · 81 citations

    2

    h-index

  2. PLoS Computational Biology

    1 publications · 62 citations

    1

    h-index

  3. Cell

    1 publications · 358 citations

    1

    h-index

  4. Cell Reports

    1 publications · 21 citations

    1

    h-index

  5. Blood

    1 publications · 97 citations

    1

    h-index

1–5