IRF-7 is the master regulator of type-I interferon-dependent immune responses

Kenya Honda, Hideyuki Yanai, Hideo Negishi, +8

Nature

InflammationAutoimmune DiseaseAllergyInnate Immune SystemImmunology +9

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Akinori Takaoka, Zhichao Wang, Myoung Kwon Choi, +9

Nature

Molecular ImmunologyInnate Immune SystemImmunologyInnate Immune ResponseCytosolic Dna Sensor +3

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

Akinori Takaoka, Hideyuki Yanai, Seiji Kondo, +8

Nature

InflammationToll-like ReceptorsCytokineSignal TransductionSignaling Pathway +9

Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

Kenya Honda, Yusuke Ohba, Hideyuki Yanai, +5

Nature

Transcriptional RegulationSignal TransductionMolecular PhysiologySignaling PathwayMolecular Regulation +11

Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence

Akinori Takaoka, Sumio Hayakawa, Hideyuki Yanai, +8

Nature

MedicineViral ImmunityImmunologyTumor ImmunityAntiviral Response +8

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

Hideyuki Yanai, Tatsuma Ban, Zhichao Wang, +15

Nature

Innate Immune SystemImmunologyImmunologic MechanismAutoimmunityInnate Immunity +3

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

Kenya Honda, Hideyuki Yanai, Tatsuaki Mizutani, +7

Proceedings of the National Academy of Sciences

Negative regulation of Toll-like-receptor signaling by IRF-4

Hideo Negishi, Yusuke Ohba, Hideyuki Yanai, +6

Proceedings of the National Academy of Sciences

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

Zhichao Wang, Myoung Kwon Choi, Tatsuma Ban, +7

Proceedings of the National Academy of Sciences

Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program

Hideo Negishi, Yasuyuki Fujita, Hideyuki Yanai, +7

Proceedings of the National Academy of Sciences

Signal Transduction PathwaysTlr ActivationInnate Immune SystemImmunologyImmune Regulation +20