Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

Florian Heil, Hiroaki Hemmi, Hubertus Hochrein, +6

Science

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa, +6

Nature Immunology

Essential FunctionViral ReplicationMolecular VirologyNatural SciencesImmunology +8

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson, +5

Nature

Natural SciencesVirulence FactorCpg MotifsMolecular BiologyDna Replication +2

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

Sandra S. Diebold, Tsuneyasu Kaisho, Hiroaki Hemmi, +2

Science

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Katherine A. Fitzgerald, Sarah M. McWhirter, L. Kerrie, +6

Nature Immunology

Signal TransductionSignaling PathwayCell RegulationMolecular RegulationGene Expression +7

Recognition of single-stranded RNA viruses by Toll-like receptor 7

Jennifer M. Lund, Lena Alexopoulou, Ayuko Sato, +5

Proceedings of the National Academy of Sciences

Toll-like Receptor 7Toll-like ReceptorsVirus StructureMolecular VirologyTlr7 Results +12

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

Sonia Sharma, Benjamin R. tenOever, Nathalie Grandvaux, +3

Science

Ikappab KinaseSignal TransductionRapid InductionInterferon Antiviral ResponseReceptor Tyrosine Kinase +12

Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

Mitsuharu Sato, Hirofumi Suemori, Naoki Hata, +8

Immunity

Transcriptional RegulationViral ReplicationMolecular VirologyViral Polymerase MechanismGenetics +13

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

Isabelle Marié

The EMBO Journal

Positive FeedbackDistinct Interferon-alpha GenesSystems BiologyMolecular VirologyMedicine +9

Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Taro Kawai, Shintaro Sato, Ken J. Ishii, +9

Nature Immunology

InflammationToll-like ReceptorsMolecular ImmunologyInterferon-α InductionSignal Transduction +12