Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

Irma García‐Martinez, Nicola Santoro, Yonglin Chen, +7

Journal of Clinical Investigation

Tlr9 PathwayImmunologyPathologyCell DeathFatty Liver Disease +22

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

Bo Hu, Chengcheng Jin, Huabing Li, +13

Science

Acute ExposureApoptosisImmunologyRadiation ExposureCell Death +17

Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program

Hideo Negishi, Yasuyuki Fujita, Hideyuki Yanai, +7

Proceedings of the National Academy of Sciences

Signal Transduction PathwaysTlr ActivationInnate Immune SystemImmunologyImmune Regulation +20

Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response

Shi‐Ying Cai, Xinshou Ouyang, Yonglin Chen, +7

JCI Insight

Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells

Yongpeng Gu, Jianfei Yang, Xinshou Ouyang, +8

European Journal of Immunology

Typical CytokinesT-regulatory CellImmunologyImmune RegulationImmunologic Mechanism +16

A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity

Hideo Negishi, Tomoko OSAWA, Kentaro Ogami, +13

Proceedings of the National Academy of Sciences

Innate Immune SystemImmunologyViral PathogenesisImmunologic MechanismInnate Immunity +16

Effect of laparoscopic Roux-en-Y gastric bypass surgery on type 2 diabetes mellitus with hypertension: A randomized controlled trial

Ziwen Liang, Qinan Wu, Bing Chen, +3

Diabetes Research and Clinical Practice

ObesityBariatric SurgeryHypertensionDiabetes ManagementSleeve Gastrectomy +6

The SGLT-2 Inhibitor Dapagliflozin Has a Therapeutic Effect on Atherosclerosis in Diabetic ApoE^−/−Mice

Weiling Leng, Xinshou Ouyang, Xiaotian Lei, +5

Mediators of Inflammation

AP-1 Activated by Toll-like Receptors Regulates Expression of IL-23 p19

Weicheng Liu, Xinshou Ouyang, Jianjun Yang, +10

Journal of Biological Chemistry

Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway

Xinshou Ouyang, Ayaz Ghani, Ahsan Malik, +5

Nature Communications

InflammationInflammatory DiseaseSignal TransductionSustained Inflammasome ActivationA2a Receptor +9