Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

Fiona M. Behan, Francesco Iorio, Gabriele Picco, +22

Nature

Crispr–cas9 ScreensGene EditingGenome EditingMedicineCell Biology +2

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

Hiroko Koike-Yusa, Yilong Li, E‐Pien Tan, +2

Nature Biotechnology

MedicineGeneticsGenetic EngineeringGene EditingGenome Editing +4

A hyperactive <i>piggyBac</i> transposase for mammalian applications

Kosuke Yusa, Liqin Zhou, Meng Amy Li, +2

Proceedings of the National Academy of Sciences

Signal TransductionDevelopmental BiologyDna TransposonsActive TranspositionProtein Expression +11

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Konstantinos Tzelepis, Hiroko Koike-Yusa, Étienne De Braekeleer, +24

Cell Reports

Gene Deletion DataGeneticsAcute Myeloid LeukemiaTherapeutic TargetsGenetic Engineering +7

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

Kosuke Yusa, S. Tamir Rashid, Hélène Strick‐Marchand, +17

Nature

α1-Antitrypsin DeficiencyInduced Pluripotent Stem CellMedicineGeneticsGene Correction +5

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

Kosuke Yusa, Roland Rad, Junji Takeda, +1

Nature Methods

Regenerative MedicineInduced Pluripotent Stem CellDevelopmental BiologyPiggybac TransposonMedicine +7

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, +20

Nature Communications

Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes

Prashant Mali, Bin-Kuan Chou, Jonathan Yen, +13

Stem Cells

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

Joshua M. Dempster, Clare Pacini, Sasha Pantel, +21

Nature Communications

<i>PiggyBac</i> Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice

Roland Rad, Lena Rad, Wei Wang, +14

Science